Deasy Bridget M, Huard Johnny
Children's Hospital of Pittsburgh, Bioengineering Department, University of Pittsburgh, PA 15213-2582, USA.
Curr Opin Mol Ther. 2002 Aug;4(4):382-9.
Skeletal muscle represents a convenient source of stem cells for cell-based tissue and genetic engineering. Muscle-derived stem cells (MDSCs) exhibit both multipotentiality and self-renewal capabilities, and are considered to be distinct from the well-studied satellite cell, another type of muscle stem cell that is capable of self-renewal and myogenic lineage differentiation. The MDSC appears to have less restricted differentiation capabilities as compared with the satellite cell, and may be a precursor of the satellite cell. This review considers the evidence for the existence of MDSCs as well as their origin. We will discuss recent investigations highlighting the potential of stem cell transplantation for the treatment of skeletal, cardiac and smooth muscle injuries and disease. We will highlight challenges in bridging the gap between understanding basic stem cell biology and clinical utilization for cell therapy.
骨骼肌是用于基于细胞的组织工程和基因工程的干细胞的便利来源。肌肉衍生干细胞（MDSCs）具有多能性和自我更新能力，并且被认为与经过充分研究的卫星细胞不同，卫星细胞是另一种能够自我更新和进行肌源性谱系分化的肌肉干细胞。与卫星细胞相比，MDSC的分化能力似乎限制较少，并且可能是卫星细胞的前体。本综述考虑了MDSC存在的证据及其起源。我们将讨论近期的研究，这些研究突出了干细胞移植在治疗骨骼肌、心肌和平滑肌损伤及疾病方面的潜力。我们将强调在弥合对基础干细胞生物学的理解与细胞治疗临床应用之间差距方面所面临的挑战。
