合众为一：多聚腺苷酸化mRNA、组蛋白mRNA和U snRNA的3'末端形成

E Pluribus Unum: 3' end formation of polyadenylated mRNAs, histone mRNAs, and U snRNAs.

作者信息

Weiner Alan M

机构信息

Department of Biochemistry, School of Medicine, University of Washington, Seattle, Washington 98195, USA.

出版信息

Mol Cell. 2005 Oct 28;20(2):168-70. doi: 10.1016/j.molcel.2005.10.009.

DOI:10.1016/j.molcel.2005.10.009

PMID:16246719

Abstract

The 3' ends of almost all eukaryotic RNAs are generated by nucleolytic cleavage. Remarkably, three groups now demonstrate that similar or identical endonucleases of the metallo-beta-lactamase family generate the 3' ends of polyadenylated mRNAs, nonpolyadenylated histone mRNAs, and U snRNAs.

摘要

几乎所有真核生物RNA的3'末端都是通过核酸酶切割产生的。值得注意的是，现在有三个研究小组表明，金属β-内酰胺酶家族中相似或相同的内切核酸酶可产生多聚腺苷酸化mRNA、非多聚腺苷酸化组蛋白mRNA和U snRNA的3'末端。