Weiner Alan M
Department of Biochemistry, School of Medicine, University of Washington, Seattle, Washington 98195, USA.
Mol Cell. 2005 Oct 28;20(2):168-70. doi: 10.1016/j.molcel.2005.10.009.
The 3' ends of almost all eukaryotic RNAs are generated by nucleolytic cleavage. Remarkably, three groups now demonstrate that similar or identical endonucleases of the metallo-beta-lactamase family generate the 3' ends of polyadenylated mRNAs, nonpolyadenylated histone mRNAs, and U snRNAs.
几乎所有真核生物RNA的3'末端都是通过核酸酶切割产生的。值得注意的是，现在有三个研究小组表明，金属β-内酰胺酶家族中相似或相同的内切核酸酶可产生多聚腺苷酸化mRNA、非多聚腺苷酸化组蛋白mRNA和U snRNA的3'末端。
