• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Rapid LC/MS/MS method development for drug discovery.

作者信息

Xu Xiaoying, Lan Jing, Korfmacher Walter A

机构信息

Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.

出版信息

Anal Chem. 2005 Oct 1;77(19):389A-394A.

PMID:16247935
Abstract
摘要

相似文献

1
Rapid LC/MS/MS method development for drug discovery.用于药物发现的快速液相色谱/串联质谱方法开发
Anal Chem. 2005 Oct 1;77(19):389A-394A.
2
Addressing the analytical throughput challenges in ADME screening using rapid ultra-performance liquid chromatography/tandem mass spectrometry methodologies.使用快速超高效液相色谱/串联质谱法应对药物代谢动力学筛选中的分析通量挑战。
Rapid Commun Mass Spectrom. 2008 Jul;22(14):2139-52. doi: 10.1002/rcm.3594.
3
Liquid chromatography tandem-mass spectrometry (LC-MS/MS)--technique and applications in endocrinology.液相色谱串联质谱法（LC-MS/MS）——技术及其在内分泌学中的应用
Exp Clin Endocrinol Diabetes. 2007 Oct;115(9):559-70. doi: 10.1055/s-2007-981458.
4
Rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of clonidine in human plasma.用于测定人血浆中可乐定的快速灵敏的液相色谱-串联质谱（LC-MS/MS）法。
J Chromatogr B Analyt Technol Biomed Life Sci. 2008 May 15;867(2):172-8. doi: 10.1016/j.jchromb.2008.03.030. Epub 2008 Apr 11.
5
Combined approach for high-throughput preparation and analysis of plasma samples from exposure studies.暴露研究中血浆样本高通量制备与分析的联合方法
Rapid Commun Mass Spectrom. 2007;21(13):1965-72. doi: 10.1002/rcm.3047.
6
Effective screening approach to select esterase inhibitors used for stabilizing ester-containing prodrugs analyzed by LC-MS/MS.通过液相色谱-串联质谱法（LC-MS/MS）分析选择用于稳定含酯前药的酯酶抑制剂的有效筛选方法。
Bioanalysis. 2010 Apr;2(4):733-43. doi: 10.4155/bio.10.30.
7
Determination of major human cytochrome P450s activities in 96-well plates using liquid chromatography tandem mass spectrometry.
Toxicol In Vitro. 2007 Oct;21(7):1247-52. doi: 10.1016/j.tiv.2007.03.022. Epub 2007 Apr 19.
8
A centralized approach to tandem mass spectrometry method development for high-throughput ADME screening.一种用于高通量药物代谢及药物相互作用筛选的串联质谱方法开发的集中式方法。
Rapid Commun Mass Spectrom. 2006;20(10):1497-503. doi: 10.1002/rcm.2469.
9
Mass spectrometric techniques for label-free high-throughput screening in drug discovery.药物发现中用于无标记高通量筛选的质谱技术。
Anal Chem. 2007 Nov 1;79(21):8207-13. doi: 10.1021/ac062421q. Epub 2007 Sep 29.
10
Large scale pesticide multiresidue methods in food combining liquid chromatography--time-of-flight mass spectrometry and tandem mass spectrometry.结合液相色谱-飞行时间质谱和串联质谱的食品中大规模农药多残留检测方法
Anal Chem. 2007 Oct 1;79(19):7308-23. doi: 10.1021/ac070855v. Epub 2007 Aug 25.

引用本文的文献

1
Quantification of Methylene Blue and Evaluation of Its Pharmacokinetics in ICR Mice by Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry Using Difluoroacetic Acid.使用二氟乙酸通过液相色谱-四极杆飞行时间质谱法对ICR小鼠体内亚甲蓝进行定量分析及其药代动力学评价
Biomed Chromatogr. 2025 Jun;39(6):e70080. doi: 10.1002/bmc.70080.
2
Occurrence and removal of psychiatric pharmaceuticals in the Tehran South Municipal Wastewater Treatment Plant.德黑兰南部城市污水处理厂中精神药物的出现和去除。
Environ Sci Pollut Res Int. 2023 Feb;30(10):27041-27055. doi: 10.1007/s11356-022-23667-5. Epub 2022 Nov 14.
3
Lessons Learned in Protein Precipitation Using a Membrane Emulsification Technique to Produce Reversible and Uniform Microbeads.
使用膜乳化技术制备可逆且均匀的微珠进行蛋白质沉淀的经验教训。
Pharmaceutics. 2021 Oct 19;13(10):1738. doi: 10.3390/pharmaceutics13101738.
4
Validation of a sensitive UHPLC-MS/MS method for cytochrome P450 probe substrates caffeine, tolbutamide, dextromethorphan, and alprazolam in human serum reveals drug contamination of serum used for research.验证一种灵敏的 UHPLC-MS/MS 法用于检测人血清中细胞色素 P450 探针底物咖啡因、甲苯磺丁脲、右美沙芬和阿普唑仑，结果显示用于研究的血清受到药物污染。
J Pharm Biomed Anal. 2020 Feb 5;179:112983. doi: 10.1016/j.jpba.2019.112983. Epub 2019 Nov 10.
5
Comparison of different serum sample extraction methods and their suitability for mass spectrometry analysis.不同血清样本提取方法的比较及其在质谱分析中的适用性。
Saudi Pharm J. 2015 Nov;23(6):689-97. doi: 10.1016/j.jsps.2015.01.023. Epub 2015 Feb 10.
6
Proteomics in the characterization of adipose dysfunction in obesity.蛋白质组学在肥胖症中脂肪功能障碍特征分析中的应用
Adipocyte. 2012 Jan 1;1(1):25-37. doi: 10.4161/adip.19129.
7
Multi-dimensional liquid chromatography in proteomics--a review.多维液相色谱在蛋白质组学中的应用综述。
Anal Chim Acta. 2010 Apr 7;664(2):101-13. doi: 10.1016/j.aca.2010.02.001. Epub 2010 Feb 6.
8
Identification and counting of carbonyl and hydroxyl functionalities in protonated bifunctional analytes by using solution derivatization prior to mass spectrometric analysis via ion-molecule reactions.通过在质谱分析前通过离子-分子反应进行溶液衍生化，鉴定和计数质子化双官能分析物中的羰基和羟基官能团。
J Am Soc Mass Spectrom. 2010 May;21(5):773-84. doi: 10.1016/j.jasms.2009.11.008. Epub 2009 Dec 4.
9
Study of transaldolase deficiency in urine samples by capillary LC-MS/MS.采用毛细管液相色谱-串联质谱法对尿液样本中的转醛醇酶缺乏症进行研究。
J Mass Spectrom. 2006 Apr;41(4):463-9. doi: 10.1002/jms.1004.