Toker Sharon, Shirom Arie, Shapira Itzhak, Berliner Shlomo, Melamed Samuel
Faculty of Management, Tel Aviv University, Tel Aviv, Israel.
J Occup Health Psychol. 2005 Oct;10(4):344-62. doi: 10.1037/1076-8998.10.4.344.
Following the demonstrated association of employee burnout or vital exhaustion with several risk factors for cardiovascular disease (CVD) and CVD risk, the authors investigated the possibility that one of the mechanisms linking burnout with CVD morbidity is microinflammation, gauged in this study by high-sensitivity C-reactive protein (hs-CRP) and fibrinogen concentrations. Their sample included 630 women and 933 men, all apparently healthy, who underwent periodic health examinations. The authors controlled for possible confounders including 2 other negative affective states: depression and anxiety. In women, burnout was positively associated with hs-CRP and fibrinogen concentrations, and anxiety was negatively associated with them. In men, depression was positively associated with hs-CRP and fibrinogen concentrations, but not with burnout or anxiety. Thus, burnout, depression, and anxiety are differentially associated with microinflammation biomarkers, dependent on gender.
鉴于已证实员工倦怠或精疲力竭与心血管疾病（CVD）的多种风险因素及CVD风险相关联，作者调查了倦怠与CVD发病率之间的一种潜在联系机制——微炎症，本研究通过高敏C反应蛋白（hs-CRP）和纤维蛋白原浓度来衡量。他们的样本包括630名女性和933名男性，所有人看起来都很健康，且都接受了定期健康检查。作者对包括另外两种负面情绪状态（抑郁和焦虑）在内的可能混杂因素进行了控制。在女性中，倦怠与hs-CRP和纤维蛋白原浓度呈正相关，而焦虑与它们呈负相关。在男性中，抑郁与hs-CRP和纤维蛋白原浓度呈正相关，但与倦怠或焦虑无关。因此，倦怠、抑郁和焦虑与微炎症生物标志物的关联因性别而异。
