Heilman C B, Kwan E S, Wu J K
Department of Neurosurgery, Tufts University School of Medicine, Boston, Massachusetts.
J Neurosurg. 1992 Aug;77(2):260-4. doi: 10.3171/jns.1992.77.2.0260.
Endovascular balloon occlusion is an alternative treatment for surgically unclippable cerebral aneurysms. The results of aneurysm occlusion with either a silicone or a latex balloon in a common carotid artery bifurcation aneurysm model are compared to determine which type of balloon was least likely to result in aneurysm recurrence. Five rabbits each underwent endovascular balloon occlusion with either a silicone or a latex balloon, with seven rabbits serving as controls. At 3 months postocclusion, nine of the 10 balloon-treated aneurysms had recurred. The recurrent aneurysm tended to be larger in animals treated with silicone than with latex balloons. A dense fibrotic response was present around the collar of the latex balloons, but no significant fibrotic response was found in the silicone balloon group. This study suggests that with currently available balloons, the initial complete angiographic obliteration of an aneurysm following balloon occlusion should not be interpreted as a cure and that periodic follow-up angiography should be performed.
血管内球囊闭塞术是手术无法夹闭的脑动脉瘤的一种替代治疗方法。比较在颈总动脉分叉动脉瘤模型中使用硅胶球囊或乳胶球囊进行动脉瘤闭塞的结果，以确定哪种类型的球囊导致动脉瘤复发的可能性最小。每组五只兔子分别接受硅胶球囊或乳胶球囊的血管内球囊闭塞术，七只兔子作为对照。闭塞后3个月，10个接受球囊治疗的动脉瘤中有9个复发。硅胶球囊治疗的动物复发的动脉瘤往往比乳胶球囊治疗的更大。乳胶球囊颈部周围出现密集的纤维化反应，但硅胶球囊组未发现明显的纤维化反应。这项研究表明，使用目前可用的球囊，球囊闭塞后动脉瘤最初的血管造影完全闭塞不应被视为治愈，而应定期进行随访血管造影。
