Patel Ayan R, Kuvin Jeffrey T, Sliney Kathleen A, Rand William M, Pandian Natesa G, Karas Richard H
Division of Cardiology, Department of Medicine, Tufts-New England Medical Center, Boston, MA 02111, USA.
Clin Cardiol. 2005 Sep;28(9):433-6. doi: 10.1002/clc.4960280909.
Vascular endothelial function has been observed to correlate with exercise capacity in predominantly male populations. Gender-based differences exist in the clinical course of coronary artery disease, and previous studies indicate that estrogen may influence endothelial function. These observations raise the possibility that the relationship between endothelial function and exercise capacity in women may differ from that in men.
This study aimed to determine whether peripheral vascular endothelial function correlates with exercise capacity in women.
Women who were referred for clinically indicated exercise testing with technetium-99 myocardial perfusion imaging were consecutively recruited. To ensure a population free of exercise limitation due to ischemic heart disease, women without myocardial perfusion defects were included for analysis in this study (n = 105). Endothelial function was assessed by brachial artery ultrasound flow-mediated vasodilation (FMD). Exercise capacity was defined as the duration of exercise on a symptom-limited Bruce protocol.
Mean FMD was 11.8 +/- 0.6%, and median FMD was 12%. Subjects with an FMD less than the median of 12% had a significantly shorter exercise time than those with FMD > or = 12% (411 +/- 17 vs. 482 +/- 24 s, p = 0.014). There was a significant correlation between FMD and exercise time (r = 0.34, p < 0.001). Age and body mass index were additional predictors of exercise time; however, the relationship between FMD and exercise time was independent of these variables.
Brachial artery FMD correlates with exercise capacity in women, even in the absence of ischemic heart disease.
在以男性为主的人群中，血管内皮功能已被观察到与运动能力相关。冠状动脉疾病的临床病程存在性别差异，先前的研究表明雌激素可能影响内皮功能。这些观察结果提示，女性内皮功能与运动能力之间的关系可能与男性不同。
本研究旨在确定外周血管内皮功能与女性运动能力是否相关。
连续招募因临床需要接受锝-99心肌灌注显像运动试验的女性。为确保研究人群不存在因缺血性心脏病导致的运动受限，本研究纳入无心肌灌注缺损的女性进行分析（n = 105）。通过肱动脉超声血流介导的血管舒张功能（FMD）评估内皮功能。运动能力定义为症状限制的布鲁斯运动试验的运动持续时间。
平均FMD为11.8 +/- 0.6%，中位数FMD为12%。FMD低于中位数12%的受试者运动时间明显短于FMD≥12%的受试者（411 +/- 17 vs. 482 +/- 24秒，p = 0.014）。FMD与运动时间之间存在显著相关性（r = 0.34，p < 0.001）。年龄和体重指数是运动时间的额外预测因素；然而，FMD与运动时间之间的关系独立于这些变量。
即使在没有缺血性心脏病的情况下，肱动脉FMD也与女性的运动能力相关。
