Atiyeh B, Husmann D, Baum M
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235-9063.
J Pediatr. 1992 Jul;121(1):65-7. doi: 10.1016/s0022-3476(05)82543-0.
Multicystic-dysplastic kidney (MCDK) disease has been associated with contralateral genitourinary tract abnormalities; however, neither the nature nor the prevalence of the contralateral renal lesion has been delineated. We retrospectively studied patients with MCDK disease to determine the prevalence of contralateral renal abnormalities and of other urologic anomalies. Forty-nine patients, ranging in age from neonates to 6 years, were examined by renal ultrasonography, excretory urography or nuclear medicine scanning, and voiding cystourethrography; 51% of the patients had an associated urologic abnormality. The abnormality was contralateral to the MCDK in 19 patients (39%), ipsilateral in 3 patients (6%), and involved the bladder wall in 3 patients (6%). The most common contralateral genitourinary tract abnormality was vesicoureteral reflux (18%) followed by ureteropelvic junction obstruction (12%). We conclude that urologic anomalies are common in patients with MCDK disease; contralateral vesicoureteral reflux is the most common abnormality identified.
多囊性发育不良肾（MCDK）疾病与对侧泌尿生殖道异常有关；然而，对侧肾脏病变的性质和发生率均未明确。我们对多囊性发育不良肾疾病患者进行了回顾性研究，以确定对侧肾脏异常和其他泌尿系统异常的发生率。对49例年龄从新生儿到6岁的患者进行了肾脏超声检查、排泄性尿路造影或核医学扫描以及排尿性膀胱尿道造影；51%的患者伴有泌尿系统异常。19例患者（39%）的异常与多囊性发育不良肾位于对侧，3例患者（6%）位于同侧，3例患者（6%）累及膀胱壁。最常见的对侧泌尿生殖道异常是膀胱输尿管反流（18%），其次是肾盂输尿管连接处梗阻（12%）。我们得出结论，泌尿系统异常在多囊性发育不良肾疾病患者中很常见；对侧膀胱输尿管反流是最常见的异常。
