Alfonso M, Adochiles L, Hendrickson V M, Carver D K, Rodriguez G C, Barnes H John
Poultry Health Management, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.
Avian Dis. 2005 Sep;49(3):430-2. doi: 10.1637/0005-2086(2005)49[430:MAITLO]2.0.CO;2.
As part of a study on ovarian and oviductal adenocarcinomas in older laying hens, 676 commercial egg-laying chickens were necropsied at 4 yr of age. Tumors were identified in 305 (45.1%) of the hens. Grossly visible metastatic tumors in the lungs of a few birds prompted collection of lungs from 228 affected hens for histologic examination. Metastatic adenocarcinomas were identified histologically in the lungs of 42 of the 228 hens (18.4%). The number of tumors and extent of involvement of the lung parenchyma varied from minimal to extensive. Tumor emboli were occasionally seen in pulmonary vessels. Metastatic foci showing expansive or invasive growth were identified. These findings indicate that vascular spread of adenocarcinomas is more common than previously thought in chickens, and the lungs are often involved with metastatic tumors, primarily from the reproductive tract.
作为一项关于老龄蛋鸡卵巢和输卵管腺癌研究的一部分，676只商品蛋鸡在4岁时进行了尸检。在305只（45.1%）母鸡中发现了肿瘤。少数鸡肺部肉眼可见转移性肿瘤，促使从228只有病变的母鸡中采集肺组织进行组织学检查。在228只母鸡中的42只（18.4%）肺组织中组织学鉴定出转移性腺癌。肿瘤数量和肺实质受累程度从轻微到广泛不等。偶尔在肺血管中可见肿瘤栓子。发现了表现为膨胀性或浸润性生长的转移灶。这些发现表明，腺癌的血管扩散在鸡中比以前认为的更常见，并且肺部经常受到转移性肿瘤的影响，主要来自生殖道。
