Forster Sarah, Gariballa Salah
Sheffield Institute for Studies on Ageing, The University of Sheffield & Barnsley Hospital, Northern General Hospital, Sheffield, S5 7AU, UK.
Nutr J. 2005 Oct 27;4:28. doi: 10.1186/1475-2891-4-28.
Undenutrition is known to be prevalent and largely unrecognised in older patients; however, aberrations in indicators of nutritional status may simply reflect effects of age and/or functional disability.
The aim of this study was to measure the effect, if any of age on nutritional status in older patients.
445 randomly selected hospitalised patients consented to nutritional status assessment derived from anthropometric, haematological, and biochemical data within 72 hours of admission. Nutritional status was compared between those age < 75 years and those aged 75 years or more. Using multiple regression models, we measured the association between age and nutritional assessment variables after adjusting for disability, chronic illness, medications, smoking and tissue inflammation.
Body weight, body mass index, mid-upper arm circumference, haemoglobin, serum albumin and plasma ascorbic acid were all significantly lower in people aged > or = 75 years compared with those < 75 years of age. Although riboflavin (vitamin B2), 25OH VitD3, red-cell folate and vitamin B12 concentrations were lower in those aged > or = 75 years, differences were not statistically significant. After adjusting for disability and co-morbidity in a multivariate analysis, age alone had a significant and independent effect on important anthropometric and biochemical nutritional assessment variables.
Increasing age is independently associated with poor nutritional status. This may partly explain the poor clinical outcome in older patients.
营养不良在老年患者中普遍存在且很大程度上未被认识到;然而,营养状况指标的异常可能仅仅反映了年龄和/或功能残疾的影响。
本研究的目的是测量年龄对老年患者营养状况的影响(如果有影响的话)。
445名随机选择的住院患者在入院72小时内同意根据人体测量、血液学和生化数据进行营养状况评估。比较了年龄<75岁和75岁及以上患者的营养状况。使用多元回归模型,在调整了残疾、慢性病、药物治疗、吸烟和组织炎症后,我们测量了年龄与营养评估变量之间的关联。
与年龄<75岁的人相比,年龄≥75岁的人的体重、体重指数、上臂中部周长、血红蛋白、血清白蛋白和血浆维生素C均显著降低。虽然年龄≥75岁的人的核黄素(维生素B2)、25OH VitD3、红细胞叶酸和维生素B12浓度较低,但差异无统计学意义。在多变量分析中调整了残疾和合并症后单独年龄对重要的人体测量和生化营养评估变量有显著且独立的影响。
年龄增长与营养状况不佳独立相关。这可能部分解释了老年患者不良的临床结局。