来自中华斑鸠菊的具有强细胞毒性活性的倍半萜内酯

Sesquiterpene lactones with potent cytotoxic activities from Vernonia chinensis.

作者信息

Chen Xin, Zhan Zha-Jun, Zhang Xiong-Wen, Ding Jian, Yue Jian-Min

机构信息

State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, P. R. China.

出版信息

Planta Med. 2005 Oct;71(10):949-54. doi: 10.1055/s-2005-871212.

DOI:10.1055/s-2005-871212

PMID:16254828

Abstract

Five new sesquiterpene lactones, namely vernchinilides A-E (1-5), along with five known compounds, 8 beta-(2-methylacryloyloxy)hirsutinolide 13-O-acetate (6), 8 alpha-(2-methylacryloyloxy)-1beta,4beta-epoxy-1alpha-methoxy-13-O-acetate-10 betaH-germacra-5 E,7(11)-dien-12,6-olide (7), 8 beta-(2-hydroxymethylacryloyloxy)hirsutinolide 13-O-acetate (8), 8 alpha-tigloyloxyhirsutinolide 13-O-acetate ( 9) and vernolide-B (10) were isolated from Vernonia chinensis. The structures of these new compounds were elucidated on the basis of spectral data, especially 2D-NMR techniques. Compounds 2, 5 and 6 exhibited potent cytotoxic activities against P-388 and A-549 tumor cell lines.

摘要

从中华斑鸠菊中分离得到了5个新的倍半萜内酯，即斑鸠菊内酯A - E（1 - 5），以及5个已知化合物，8β-(2 - 甲基丙烯酰氧基)水苏内酯13 - O - 乙酸酯（6）、8α-(2 - 甲基丙烯酰氧基)-1β,4β - 环氧 - 1α - 甲氧基 - 13 - O - 乙酸酯 - 10βH - 吉马烯 - 5E,7(11) - 二烯 - 12,6 - 内酯（7）、8β-(2 - 羟甲基丙烯酰氧基)水苏内酯13 - O - 乙酸酯（8）、8α - 惕各酰氧基水苏内酯13 - O - 乙酸酯（9）和斑鸠菊内酯 - B（10）。这些新化合物的结构通过光谱数据，尤其是二维核磁共振技术得以阐明。化合物2、5和6对P - 388和A - 549肿瘤细胞系表现出较强的细胞毒活性。