Wang Xiao-Xiong, Lin Chang-Jun, Jia Zhong-Jian
National Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, P. R. China.
Planta Med. 2006 Jun;72(8):764-7. doi: 10.1055/s-2006-941508. Epub 2006 Jun 19.
The chemical investigation of Mulgedium tataricum afforded six new compounds which were identified as lanost-9(11),23 Z(24)-diene-3beta,25-diol (1), lanost-9(11),25-diene-3beta,24beta-diol (2), ursane-20-ene-3beta,22alpha-diol (3), 4 E,10 E-3beta,11beta-dihydroxygermacra-4(5),10(1)-dien-12,6alpha-olide (4), 4 E-1beta-hydroperoxy-3beta,11beta-dihydroxygermacra-4(5),10(14)-dien-12,6alpha-olide (5) and lactucin-8-O-P-methoxyphenyl acetate (6) by using a combination of MS and NMR techniques. Compound 6 exhibited significant cytotoxicity against cultured human hepatoma cells (SMMC-7721) and human acute promyelocytic leukemia cells (HL60). The antibacterial activity study indicated that 1 and 2 strongly inhibited the growth of Escherichia coli.
对鞑靼苦菜的化学研究得到了六种新化合物，通过质谱和核磁共振技术相结合的方法，它们被鉴定为羊毛甾-9(11),23Z(24)-二烯-3β,25-二醇（1）、羊毛甾-9(11),25-二烯-3β,24β-二醇（2）、乌苏烷-20-烯-3β,22α-二醇（3）、4E,10E-3β,11β-二羟基吉马-4(5),10(1)-二烯-12,6α-内酯（4）、4E-1β-氢过氧基-3β,11β-二羟基吉马-4(5),10(14)-二烯-12,6α-内酯（5）和莴苣素-8-O-p-甲氧基苯基乙酸酯（6）。化合物6对培养的人肝癌细胞（SMMC-7721）和人急性早幼粒细胞白血病细胞（HL60）表现出显著的细胞毒性。抗菌活性研究表明，1和2强烈抑制大肠杆菌的生长。
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