一年蓬中的新倍半萜类化合物。

New sesquiterpenes from Erigeron annus.

作者信息

Li Xin, Yang Min, Han Yi-Feng, Gao Kun

机构信息

College of Chemistry and Chemical Engineering, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, People's Republic of China.

出版信息

Planta Med. 2005 Mar;71(3):268-72. doi: 10.1055/s-2005-837827.

DOI:10.1055/s-2005-837827

PMID:15770549

Abstract

Four new and five known eudesmane-type sesquiterpenes were isolated from the aerial parts of Erigeron annus. The structures of these new compounds were elucidated by spectral means, including 2D-NMR analysis, to be 1 beta,4 beta-dihydroxyeudesman-11-ene; 1 beta,7 alpha-dihydroxyeudesman-4(15)-ene; (1 R,5 S,6 S,7 S,10 R)-1 beta, 6 alpha-dihydroxyeudesman-4-one and 1 beta- D-glucopyranosyloxy-6 alpha-hydroxyeudesman-4(15)-ene. In addition, a chemical transformation of a known compound 1 beta,6 alpha-dihydroxy-eudesman-4 (15)-ene was carried out and the derivative 1beta,6alpha-dihydroxy-4beta(15)-epoxyeudesmane was obtained. Some of the compounds were evaluated for their in vitro antitumor activities.

摘要

从一年蓬地上部分分离得到4个新的和5个已知的桉叶烷型倍半萜。通过光谱手段，包括二维核磁共振分析，阐明了这些新化合物的结构，分别为1β,4β - 二羟基桉叶-11-烯；1β,7α - 二羟基桉叶-4(15)-烯；(1R,5S,6S,7S,10R)-1β,6α - 二羟基桉叶-4-酮和1β - D - 吡喃葡萄糖氧基-6α - 羟基桉叶-4(15)-烯。此外，对已知化合物1β,6α - 二羟基桉叶-4(15)-烯进行了化学转化，得到了衍生物1β,6α - 二羟基-4β(15)-环氧桉叶烷。对其中一些化合物进行了体外抗肿瘤活性评价。