奖赏与动机的前脑基质。
Forebrain substrates of reward and motivation.
作者信息
Wise Roy A
机构信息
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA.
出版信息
J Comp Neurol. 2005 Dec 5;493(1):115-21. doi: 10.1002/cne.20689.
Abstract
Electrical stimulation of the medial forebrain bundle can reward arbitrary acts or motivate biologically primitive, species-typical behaviors like feeding or copulation. The subsystems involved in these behaviors are only partially characterized, but they appear to transsynaptically activate the mesocorticolimbic dopamine system. Basal function of the dopamine system is essential for arousal and motor function; phasic activation of this system is rewarding and can potentiate the effectiveness of reward-predictors that guide learned behaviors. This system is phasically activated by most drugs of abuse and such activation contributes to the habit-forming actions of these drugs.
摘要
对内侧前脑束进行电刺激可以奖赏任意行为，或激发诸如进食或交配等生物学上原始的、物种典型的行为。参与这些行为的子系统仅得到部分表征，但它们似乎通过突触激活中脑皮质边缘多巴胺系统。多巴胺系统的基础功能对于觉醒和运动功能至关重要；该系统的相位性激活具有奖赏作用，并且可以增强引导学习行为的奖赏预测因子的有效性。该系统会被大多数滥用药物相位性激活，这种激活作用促成了这些药物的成瘾行为。
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