Phillips A G
Brain Res Bull. 1984 Feb;12(2):195-201. doi: 10.1016/0361-9230(84)90189-8.
Anatomical, lesion and pharmacological data pertaining to intracranial self-stimulation are reviewed in the context of multiple independent substrates of brain-stimulation reward. Subsystems related to chemosensitive pathways, motor control and mood are identified. Forebrain dopamine pathways are recognized to be important components of two separate subsystems of reward. Nigrostriatal DA neurons are linked to an extrapyramidal circuit with reinforcement derived from response initiation and it is conjectured that the meso-limbic DA pathway is related to the control and perception of positive affect. Other candidate systems include a trigeminal system in the hind brain that may function independently from forebrain substrates of reward.
在脑刺激奖赏的多个独立底物的背景下，回顾了与颅内自我刺激相关的解剖学、损伤和药理学数据。确定了与化学敏感通路、运动控制和情绪相关的子系统。前脑多巴胺通路被认为是两个独立奖赏子系统的重要组成部分。黑质纹状体多巴胺能神经元与一个锥体外系回路相连，其强化源于反应启动，据推测中脑边缘多巴胺能通路与积极情感的控制和感知有关。其他候选系统包括后脑的三叉神经系统，它可能独立于前脑奖赏底物发挥作用。
