• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

不同酚类化合物对α-淀粉酶活性的影响：基于酶标仪动力学检测法的筛选

Effect of different phenolic compounds on alpha-amylase activity: screening by microplate-reader based kinetic assay.

作者信息

Funke I, Melzig M F

机构信息

Institut für Pharmazie, Freie Universität, Berlin, Germany.

出版信息

Pharmazie. 2005 Oct;60(10):796-7.

PMID:16259133
Abstract

The inhibitory effect of different polyphenolic plant compounds on alpha-amylase activity was investigated in vitro. A kinetic assay was performed using 96-well-plates. Acarbose was used as positive control (IC50: 23.2 microM). Some of the tested compounds, occurring in plants traditionally used in anti-diabetic tea species, showed an inhibition of the enzyme in physiological concentrations, e.g. luteolin, tannic acid, and isochlorogenic acid.

摘要

在体外研究了不同多酚类植物化合物对α-淀粉酶活性的抑制作用。使用96孔板进行动力学测定。阿卡波糖用作阳性对照（IC50：23.2微摩尔）。一些存在于传统用于抗糖尿病茶品种的植物中的受试化合物，在生理浓度下显示出对该酶的抑制作用，例如木犀草素、单宁酸和异绿原酸。

相似文献

1
Effect of different phenolic compounds on alpha-amylase activity: screening by microplate-reader based kinetic assay.不同酚类化合物对α-淀粉酶活性的影响：基于酶标仪动力学检测法的筛选
Pharmazie. 2005 Oct;60(10):796-7.
2
Berry polyphenols inhibit α-amylase in vitro: identifying active components in rowanberry and raspberry.树莓和覆盆子中的多酚抑制α-淀粉酶的体外活性：鉴定活性成分。
J Agric Food Chem. 2011 Mar 23;59(6):2324-31. doi: 10.1021/jf1045359. Epub 2011 Feb 17.
3
alpha-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus.一些用于治疗糖尿病的马来西亚植物的α-淀粉酶抑制活性；特别提及苦味叶下珠。
J Ethnopharmacol. 2006 Oct 11;107(3):449-55. doi: 10.1016/j.jep.2006.04.004. Epub 2006 Apr 18.
4
In vitro alpha amylase inhibitory effect of some clinically-used drugs.某些临床用药的体外α淀粉酶抑制作用
Pharmazie. 2004 Oct;59(10):799-801.
5
Anti-diabetic and anti-hypertensive potential of sprouted and solid-state bioprocessed soybean.发芽及固态生物加工大豆的抗糖尿病和抗高血压潜力
Asia Pac J Clin Nutr. 2005;14(2):145-52.
6
Antihyperglycemic effects of total flavonoids from Polygonatum odoratum in STZ and alloxan-induced diabetic rats.玉竹总黄酮对链脲佐菌素和四氧嘧啶诱导的糖尿病大鼠的降血糖作用。
J Ethnopharmacol. 2009 Jul 30;124(3):539-43. doi: 10.1016/j.jep.2009.05.006. Epub 2009 May 18.
7
The multi-targets integrated fingerprinting for screening anti-diabetic compounds from a Chinese medicine Jinqi Jiangtang Tablet.基于中药津芪降糖片的多靶整合指纹图谱用于抗糖尿病化合物的筛选。
J Ethnopharmacol. 2015 Apr 22;164:210-22. doi: 10.1016/j.jep.2015.02.018. Epub 2015 Feb 16.
8
In vitro studies of Gynura divaricata (L.) DC extracts as inhibitors of key enzymes relevant for type 2 diabetes and hypertension.翻茄苣（L.）DC 提取物作为 2 型糖尿病和高血压相关关键酶抑制剂的体外研究。
J Ethnopharmacol. 2011 Jun 22;136(2):305-8. doi: 10.1016/j.jep.2011.04.059. Epub 2011 May 6.
9
Anti-diabetic Phenolic Compounds of Black Carrot (Daucus carota Subspecies sativus var. atrorubens Alef.) Inhibit Enzymes of Glucose Metabolism: An in silico and in vitro Validation.黑胡萝卜（Daucus carota Subspecies sativus var. atrorubens Alef.）的抗糖尿病酚类化合物抑制葡萄糖代谢酶：计算机模拟和体外验证
Med Chem. 2018;14(6):641-649. doi: 10.2174/1573406414666180301092819.
10
Phenolic group on A-ring is key for dracoflavan B as a selective noncompetitive inhibitor of α-amylase.A环上的酚羟基基团是龙血黄素B作为α-淀粉酶选择性非竞争性抑制剂的关键所在。
Bioorg Med Chem. 2015 Dec 15;23(24):7641-9. doi: 10.1016/j.bmc.2015.11.008. Epub 2015 Nov 11.

引用本文的文献

1
Unveiling the Phytochemical Diversity and Bioactivity of : A First Report Integrating Experimental and In Silico Approaches.揭示：整合实验和计算机模拟方法的首份报告中的植物化学多样性和生物活性。 （注：原文中冒号前缺少具体内容，译文根据语境补充完整，使其更通顺，但严格按照要求未添加额外解释说明。）
Pharmaceuticals (Basel). 2025 Jan 15;18(1):103. doi: 10.3390/ph18010103.
2
Exploring the Antidiabetic Potential of Using Network Pharmacology, Molecular Docking and ADME/Drug-Likeness Predictions.利用网络药理学、分子对接以及ADME/药物相似性预测探索抗糖尿病潜力
Plants (Basel). 2024 Oct 16;13(20):2892. doi: 10.3390/plants13202892.
3
Polyphenol Profile of × L. and Its Relevance to Antioxidant Effect and α-Glucosidase Inhibition.
×L.的多酚概况及其与抗氧化作用和α-葡萄糖苷酶抑制的相关性。
Antioxidants (Basel). 2023 Feb 22;12(3):553. doi: 10.3390/antiox12030553.
4
UPLC-ESI-QTOF-MS Profiling of Phenolic Compounds from : In Vitro Antioxidant, Antidiabetic, and Anti-Inflammatory Potentials.UPLC-ESI-QTOF-MS 分析：体外抗氧化、抗糖尿病和抗炎潜力的酚类化合物。
Molecules. 2022 Dec 15;27(24):8912. doi: 10.3390/molecules27248912.
5
Antioxidant activity and antidiabetic activities of Northern Thai indigenous edible plant extracts and their phytochemical constituents.泰国北部本土可食用植物提取物及其植物化学成分的抗氧化活性和抗糖尿病活性。
Heliyon. 2022 Sep 23;8(9):e10740. doi: 10.1016/j.heliyon.2022.e10740. eCollection 2022 Sep.
6
Efficacy of aqueous extract on inhibition of α-amylase enzyme activity and insulin resistance in dexamethasone treated-rats.水提取物对抑制地塞米松处理大鼠的α-淀粉酶活性和胰岛素抵抗的功效。
Metabol Open. 2022 Jun 2;15:100193. doi: 10.1016/j.metop.2022.100193. eCollection 2022 Sep.
7
Lignocellulose Fermentation Products Generated by Giant Panda Gut Microbiomes Depend Ultimately on pH Rather than Portion of Bamboo: A Preliminary Study.大熊猫肠道微生物群产生的木质纤维素发酵产物最终取决于pH值而非竹子的比例：一项初步研究。
Microorganisms. 2022 May 7;10(5):978. doi: 10.3390/microorganisms10050978.
8
Effects of two contrasting dietary polysaccharides and tannic acid on the digestive and physicochemical properties of wheat starch.两种不同的膳食多糖和单宁酸对小麦淀粉消化及理化性质的影响。
Food Sci Nutr. 2021 Aug 31;9(10):5800-5808. doi: 10.1002/fsn3.2559. eCollection 2021 Oct.
9
Influence of In Vitro Human Digestion Simulation on the Phenolics Contents and Biological Activities of the Aqueous Extracts from Turkish Species.体外人体消化模拟对土耳其 品种水提物中酚类物质含量和生物活性的影响。
Molecules. 2021 Sep 1;26(17):5322. doi: 10.3390/molecules26175322.
10
UHPLC-DAD Characterization of L. from Atacama Desert Andean Region and Antioxidant, Antibacterial and Enzyme Inhibition Activities.超高效液相色谱-二极管阵列检测法对安第斯山区阿塔卡马沙漠 L. 的表征及抗氧化、抗菌和抑制酶活性的研究
Molecules. 2021 Apr 6;26(7):2100. doi: 10.3390/molecules26072100.