Laboratorio de Química Orgánica y Productos Naturales, Facultad de Ciencias Agronómicas, Universidad de Tarapacá, Av. General Velásquez 1775, Arica 1000000, Chile.
Life Sciences Innovation Center, University of California Davis Chile, Santiago 7511303, Chile.
Molecules. 2021 Apr 6;26(7):2100. doi: 10.3390/molecules26072100.
The Lamiaceae family is an important source of species among medicinal plants highly valued for their biological properties and numerous uses in folk medicine. is one of the main genera that belong to this family. The purpose of the study was to determine the phenolic composition of the extract and evaluate the antimicrobial, antioxidant, and inhibitory activities of this species that grows in the Andean region of the Atacama Desert. High-performance liquid chromatography was performed to determine the main phenols. Rosmarinic acid was identified as the predominant phenolic compound in this species (76.01 mg/100 g DW), followed by protocatechuic acid, which to our knowledge, no previous study reported similar concentrations in . The oregano extract exhibited a content of total phenolic (3948 mg GAE/100 g DW) and total flavonoid (593 mg QE/100 g DW) with a higher DPPH antioxidant activity (IC = 40.58 µg/mL), compared to the same species grown under other conditions. Furthermore, it was found to inhibit α-glucosidase activity with an IC value (7.11 mg/mL) lower than acarbose (129.32 mg/mL). and (both MIC 0.313 mg/mL and MBC 1.25 mg/mL) were the bacteria most susceptible to oregano extract with the lowest concentration necessary to inhibit bacterial growth. These results open the door for the potential use of this plant to manage chronic diseases, and they expand the knowledge of the species cultivated in arid environmental conditions.
唇形科是具有生物特性和在民间医学中具有多种用途的药用植物的重要物种来源。迷迭香属是该科的主要属之一。本研究的目的是确定 提取物的酚类成分，并评估该物种在安第斯山脉阿塔卡马沙漠地区生长的抗菌、抗氧化和抑制活性。采用高效液相色谱法测定主要酚类化合物。迷迭香酸被确定为该物种中主要的酚类化合物（76.01mg/100gDW），其次是原儿茶酸，据我们所知，以前没有研究报道过 在 中的类似浓度。与在其他条件下生长的同种植物相比，牛至提取物的总酚（3948mgGAE/100gDW）和总类黄酮（593mgQE/100gDW）含量较高，DPPH抗氧化活性（IC=40.58μg/mL）也较高。此外，它被发现抑制α-葡萄糖苷酶活性的 IC 值（7.11mg/mL）低于阿卡波糖（129.32mg/mL）。 和 （均 MIC0.313mg/mL和MBC1.25mg/mL）是对牛至提取物最敏感的细菌，抑制细菌生长所需的最低浓度。这些结果为该植物在慢性病管理中的潜在用途开辟了道路，并扩展了在干旱环境条件下种植的该物种的知识。
