Urso C, Bondi R, Balzi M, Scubla E, Mauri P, Becciolini A, Tarocchi S, Vallecchi C
Istituto di Anatomia e Istologia Patologica, Università di Firenze, Italy.
Pathol Res Pract. 1992 Apr;188(3):323-9. doi: 10.1016/s0344-0338(11)81212-4.
The 3H-thymidine labelling (LI) and mitotic (MI) indexes were calculated in 29 cutaneous melanocytic lesions: 6 common nevi (CN), 11 dysplastic nevi, subclassified as nevi with architectural atypia (NAA = 4) and nevi with cyto-architectural atypia (NCAA = 7), 2 melanomas in situ (MIS), 4 invasive superficial spreading melanomas (IM) and 6 metastatic melanomas (MM). The LI mean values resulted to be: CN = 0.23%, NAA = 0.98%, NCAA = 1.79%, MIS = 5.75%, IM = 5.16%, MM = 3.80%. In CN, NAA, NCAA and MIS, these values were calculated at epidermal level; in IM and MM at dermal level. At dermal level, the LI mean values of CN, NAA and NCAA were: 0.20%, 0.20%, 0.23% respectively. The MI mean value was close to 0 in CN, NAA, NCAA, MIS; 0.18% in IM, 0.16% in MM. Confirming a low proliferative activity in CN and a high activity in melanomas (MIS, IM, MM), the results showed that dysplastic nevi (NAA, NCAA) had a proliferative activity intermediate between common nevi and melanomas. The lesions with melanocytic atypia (NCAA) resulted to have a higher proliferative activity than those without this histological feature (NAA).
在29例皮肤黑素细胞性病变中计算了³H-胸腺嘧啶核苷标记指数（LI）和有丝分裂指数（MI）：6例普通痣（CN）、11例发育异常痣，再分为具有结构异型性的痣（NAA = 4）和具有细胞结构异型性的痣（NCAA = 7）、2例原位黑素瘤（MIS）、4例侵袭性浅表扩散性黑素瘤（IM）和6例转移性黑素瘤（MM）。LI平均值结果如下：CN = 0.23%，NAA = 0.98%，NCAA = 1.79%，MIS = 5.75%，IM = 5.16%，MM = 3.80%。在CN、NAA、NCAA和MIS中，这些值在表皮水平计算；在IM和MM中在真皮水平计算。在真皮水平，CN、NAA和NCAA的LI平均值分别为：0.20%、0.20%、0.23%。MI平均值在CN、NAA、NCAA、MIS中接近0；在IM中为0.18%，在MM中为0.16%。结果证实CN的增殖活性低，黑素瘤（MIS、IM、MM）的活性高，表明发育异常痣（NAA、NCAA）的增殖活性介于普通痣和黑素瘤之间。具有黑素细胞异型性的病变（NCAA）的增殖活性高于无此组织学特征的病变（NAA）。
