Yoffe Rona, Khakoo Yasmin, Dunkel Ira J, Souweidane Mark, Lis Eric, Sklar Charles
Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Pediatr Blood Cancer. 2007 Oct 15;49(5):758-60. doi: 10.1002/pbc.20647.
Due to high rates of recurrence, the prognosis of childhood ependymoma remains guarded. Anecdotal evidence suggests that tamoxifen may have a role in the treatment of these tumors. We present a case of a child with recurrent ependymoma treated with tamoxifen who showed tumor regression on two separate occasions. However, treatment with tamoxifen resulted in the development of large ovarian cysts associated with supraphysiological plasma concentrations of estradiol.
由于复发率高，儿童室管膜瘤的预后仍不容乐观。有轶事证据表明他莫昔芬可能在这些肿瘤的治疗中发挥作用。我们报告一例复发性室管膜瘤患儿，接受他莫昔芬治疗，肿瘤在两个不同时间出现消退。然而，他莫昔芬治疗导致出现与超生理浓度雌二醇相关的巨大卵巢囊肿。
