Levin Michael E, Motala Cassim, Lopata Andreas L
Allergy Clinic, School of Child and Adolescent Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa.
Pediatrics. 2005 Nov;116(5):1223-5. doi: 10.1542/peds.2005-0020.
In this report we describe a 9-month-old boy with severe persistent asthma and documented cow's milk allergy (presented with eczema and severe systemic reactions) who had an anaphylactic reaction to a soy formula contaminated with cow's milk protein. Quantitative enzyme-linked immunosorbent assay analysis revealed trace quantities of beta-lactoglobulin in the offending soy formula as well as the dry powder. The patient did not demonstrate clinical reactivity to soy protein (negative challenge, tolerated pure soy formula well). Cross-contamination of the offending soy formula was presumed to have occurred during food manufacturing. This case demonstrates that trace quantities of cow's milk protein can elicit severe systemic reactions in highly milk-allergic individuals. This infant ingested the equivalent of 0.4 mL of cow's milk from the soy formula as documented by an immunoassay for beta-lactoglobulin. This highlights the ease with which cross-contamination can occur during food processing and reinforces the need for better quality control.
在本报告中，我们描述了一名9个月大的患有严重持续性哮喘且有牛奶过敏记录（表现为湿疹和严重全身反应）的男孩，他对被牛奶蛋白污染的大豆配方奶粉发生了过敏反应。定量酶联免疫吸附测定分析显示，问题大豆配方奶粉以及干粉中存在微量的β-乳球蛋白。该患者对大豆蛋白未表现出临床反应性（激发试验阴性，能很好地耐受纯大豆配方奶粉）。据推测，问题大豆配方奶粉的交叉污染发生在食品生产过程中。该病例表明，微量的牛奶蛋白可在对牛奶高度过敏的个体中引发严重的全身反应。通过β-乳球蛋白免疫测定记录，该婴儿从大豆配方奶粉中摄入了相当于0.4毫升牛奶的量。这凸显了食品加工过程中交叉污染发生的容易程度，并强化了加强质量控制的必要性。
