Dawson D A, Harford T C, Grant B F
National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland 20857.
Alcohol Clin Exp Res. 1992 Jun;16(3):572-5. doi: 10.1111/j.1530-0277.1992.tb01419.x.
The effects of various levels of positive family history of alcoholism on the probability of past year alcohol dependence were investigated using a general population sample of 23,152 drinkers 18 years of age and older. Forty percent reported a positive family history. After adjustment for age, race, gender, and poverty and compared with persons with a negative family history, the odds of alcohol dependence were increased by 45% among persons with alcoholism in second or third degree relatives only, by 86% among those with alcoholism in first degree relatives only, and by 167% among those with alcoholism in first and second or third degree relatives. The effects of family history did not vary among population subgroups as defined by age, race, gender, and poverty.
利用一个包含23152名18岁及以上饮酒者的普通人群样本，研究了不同程度的酒精中毒阳性家族史对过去一年酒精依赖可能性的影响。40%的人报告有阳性家族史。在对年龄、种族、性别和贫困状况进行调整后，与家族史阴性的人相比，只有二级或三级亲属患有酒精中毒的人，酒精依赖的几率增加了45%；只有一级亲属患有酒精中毒的人，酒精依赖的几率增加了86%；一级亲属以及二级或三级亲属患有酒精中毒的人，酒精依赖的几率增加了167%。家族史的影响在按年龄、种族、性别和贫困状况定义的人群亚组中没有差异。
