Tambs K, Vaglum P
Department of Behavioural Sciences in Medicine, University of Oslo, Norway.
Acta Psychiatr Scand. 1990 Aug;82(2):145-51. doi: 10.1111/j.1600-0447.1990.tb01372.x.
Alcohol consumption was recorded for 2390 spouses and 498 children of age 18 or above living with their parents. The spouse correlation was 0.67, whereas parent-offspring and sibling correlations were all close to 0.35. This family correlation structure implies an upper limit for heritability of 0.44. The design does not permit a separation of effect of cultural (environmental) and genetic transmission in families, but comparisons with previous heritability analyses suggest that heritability is in fact close to the upper limit, implying little or no cultural transmission. There were virtually no correlations between alcohol consumption and symptoms of anxiety and depression. Nor did consumption correlate substantially with symptoms in first-degree relatives. These results do not support hypotheses of common genetic nor even of common environmental determinants for alcohol consumption and mental disorders.
记录了2390名配偶以及与父母同住的498名18岁及以上子女的饮酒情况。配偶之间的相关性为0.67，而父母与子女以及兄弟姐妹之间的相关性均接近0.35。这种家庭相关性结构意味着遗传率的上限为0.44。该设计不允许区分家庭中文化（环境）和基因传递的影响，但与之前的遗传率分析比较表明，遗传率实际上接近上限，这意味着几乎没有文化传递。饮酒与焦虑和抑郁症状之间几乎没有相关性。饮酒与一级亲属的症状也没有显著相关性。这些结果不支持关于饮酒和精神障碍存在共同基因甚至共同环境决定因素的假设。
