Herrera-Trujillo Mónica, Barraza-Villarreal Albino, Lazcano-Ponce Eduardo, Hernández Bernardo, Sanín Luz Helena, Romieu Isabelle
Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México, and Department of Public-Health Sciences, University of Toronto, Ontario, Canada.
J Asthma. 2005 Oct;42(8):705-9. doi: 10.1080/02770900500265306.
Studies suggest an association between obesity and asthma. This may be modified by the physiological changes of puberty. We aim to explore the relation between overweight and current asthma among Mexican adolescent females and young women and evaluate how puberty may modify this association.
Adolescent females (n=6944) and young women aged 11-24 years provided data. Current asthma was defined as wheezing in the last 12 months and obesity by body mass index (BMI). Puberty was defined by age at menarche. The association of obesity and current wheezing was evaluated by using logistic regression adjusting for confounders. The impact of puberty was studied by using stratified analysis by age at menarche.
The prevalence of current wheezing was 16.2% (95% CI 15-17). Compared with girls of normal weight (BMI 15 to >or=85 percentile), obese girls (BMI>or=95 percentile) had an increased risk of current wheezing of 19% (OR=1.19; 95% CI 0.97-1.46). After stratifying by age at menarche, we observed that this increased risk was only present in girls with menarche at 11 years old or younger (1.31%; 95% CI 1.01-1.73).
The association between obesity and asthma seems to be greater among girls with early puberty, suggesting the role of female hormones.
研究表明肥胖与哮喘之间存在关联。青春期的生理变化可能会改变这种关联。我们旨在探讨墨西哥青春期女性和年轻女性中超重与当前哮喘之间的关系，并评估青春期如何改变这种关联。
11 - 24岁的青春期女性（n = 6944）和年轻女性提供了数据。当前哮喘定义为过去12个月内有喘息，肥胖通过体重指数（BMI）定义。青春期通过初潮年龄定义。使用逻辑回归并对混杂因素进行调整来评估肥胖与当前喘息之间的关联。通过按初潮年龄进行分层分析来研究青春期的影响。
当前喘息的患病率为16.2%（95%置信区间15 - 17）。与正常体重女孩（BMI在第15至≥85百分位）相比，肥胖女孩（BMI≥95百分位）当前喘息的风险增加了19%（比值比 = 1.19；95%置信区间0.97 - 1.46）。按初潮年龄分层后，我们观察到这种增加的风险仅在初潮年龄为11岁或更小的女孩中存在（1.31%；95%置信区间1.01 - 1.73）。
肥胖与哮喘之间的关联在青春期较早的女孩中似乎更强，提示女性激素的作用。
