Michot F, Ajdacic K, Glaus L
Bezirksspital, Laufenburg (Aargau), Switzerland.
J Int Med Res. 1975;3(3):153-7. doi: 10.1177/030006057500300303.
A double-blind crossover trial between diclofenac sodium and placebo was carried out in 32 hospitalized patients who were thought to be stabilized on concurrent anticoagulant therapy with acenocoumarol. The object of the trial was to investigate any possible interaction between diclofenac and anticoagulant by monitoring prothrombin times daily through the four week period. No statistically significant difference between placebo and diclofenac could be shown and some problems of accurately monitoring prothrombin times are discussed.
在32名住院患者中进行了双氯芬酸钠与安慰剂的双盲交叉试验，这些患者被认为在用醋硝香豆素进行的抗凝治疗中病情已稳定。试验目的是通过在四周时间内每日监测凝血酶原时间来研究双氯芬酸与抗凝剂之间可能存在的相互作用。未发现安慰剂与双氯芬酸钠之间有统计学上的显著差异，并讨论了准确监测凝血酶原时间的一些问题。
