博德特氏菌属泰国种基于肌动蛋白的运动需要 BimA 的中央酸性结构域，该结构域募集并激活细胞的 Arp2/3 复合物。
Actin-based motility of Burkholderia thailandensis requires a central acidic domain of BimA that recruits and activates the cellular Arp2/3 complex.
机构信息
Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkoknoi, Bangkok 10700, Thailand.
出版信息
J Bacteriol. 2010 Oct;192(19):5249-52. doi: 10.1128/JB.00608-10. Epub 2010 Aug 6.
Abstract
Burkholderia species use BimA for intracellular actin-based motility. Uniquely, Burkholderia thailandensis BimA harbors a central and acidic (CA) domain. The CA domain was required for actin-based motility, binding to the cellular Arp2/3 complex, and Arp2/3-dependent polymerization of actin monomers. Our data reveal distinct strategies for actin-based motility among Burkholderia species.
摘要
伯克霍尔德氏菌属物种利用 BimA 进行细胞内基于肌动蛋白的运动。独特的是，泰国伯克霍尔德氏菌 BimA 具有中央和酸性 (CA) 结构域。CA 结构域对于基于肌动蛋白的运动、与细胞内的 Arp2/3 复合物结合以及 Arp2/3 依赖的肌动蛋白单体聚合是必需的。我们的数据揭示了伯克霍尔德氏菌属物种中基于肌动蛋白的运动的不同策略。
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