从1,4 - 双环氧化合物开始的对呋喃糖类衍生物的立体选择性环化反应。

A stereoselective cyclization to carbafuranose derivatives starting from 1,4-bis-epoxides.

作者信息

Leung Leo M H, Boydell A James, Gibson Vicky, Light Mark E, Linclau Bruno

机构信息

School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, United Kingdom.

出版信息

Org Lett. 2005 Nov 10;7(23):5183-6. doi: 10.1021/ol052009h.

DOI:10.1021/ol052009h

PMID:16268533

Abstract

[reactions: see text] A concise synthesis of highly functionalized cyclopentane derivatives via a Brook rearrangement mediated stereoselective linchpin cyclization reaction involving tert-butyldimethylsilyl-1,3-dithianyllithium and homochiral 1,4-bis-epoxides is described.

摘要

[反应：见正文] 描述了一种通过涉及叔丁基二甲基甲硅烷基-1,3-二噻烷锂和同手性1,4-双环氧化物的布鲁克重排介导的立体选择性关键环化反应，简洁合成高度官能化环戊烷衍生物的方法。