基于（N'(1)E，N'(3)E）-N'(1)，N'(3)-双（3,4,5-取代亚苄基）丙二酰肼在溶剂热条件下合成一些新型3,5-双（取代）吡唑和异恶唑
Synthesis of Some New 3, 5-Bis (substituted) Pyrazoles and Isoxazoles Based on (N'(1)E, N'(3)E)- N'(1), N'(3)-Bis (3, 4, 5-substitutedbenzlidene) Malonohydrazide under Solvothermal Conditions.
作者信息
Abdu Musad Ebraheem, Lokanatha Rai Kuriya Madavu, Byrappa Kullaiah
机构信息
Department of Chemistry, University of Mysore, Manasagangotri, Mysore, India;
出版信息
Int J Biomed Sci. 2010 Mar;6(1):45-8.
The new 3,5-(substituted) pyrazoles and isoxazoles were prepared by reaction of (N'(1)E, N'(3)E)- N'(1), N'(3)-bis (3,4,5-substitutedbenzylidene)malonohydrazide with hydrazine hydrate and hydroxylamine hydrochloride respectively under solvothermal conditions involving an ecofriendly method without any environmental pollution, the yield are in the range of 75-96%. The structure of the new compounds were established using elemental analysis, IR, (1)H NMR, (13)C NMR.
新型3,5-（取代）吡唑和异恶唑是通过（N'(1)E, N'(3)E）-N'(1), N'(3)-双（3,4,5-取代苄叉基）丙二酰肼分别与水合肼和盐酸羟胺在溶剂热条件下反应制备的，该方法是一种环保方法，无任何环境污染，产率在75 - 96%范围内。利用元素分析、红外光谱、(1)H核磁共振、(13)C核磁共振确定了新化合物的结构。
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