Butt K M, Smith Gavin J D, Chen Honglin, Zhang L J, Leung Y H Connie, Xu K M, Lim Wilina, Webster Robert G, Yuen K Y, Peiris J S Malik, Guan Yi
Department of Microbiology, The University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong SAR, People's Republic of China.
J Clin Microbiol. 2005 Nov;43(11):5760-7. doi: 10.1128/JCM.43.11.5760-5767.2005.
Avian H9N2 influenza A virus has caused repeated human infections in Asia since 1998. Here we report that an H9N2 influenza virus infected a 5-year-old child in Hong Kong in 2003. To identify the possible source of the infection, the human isolate and other H9N2 influenza viruses isolated from Hong Kong poultry markets from January to October 2003 were genetically and antigenically characterized. The findings of this study show that the human H9N2 influenza virus, A/Hong Kong/2108/03, is of purely avian origin and is closely related to some viruses circulating in poultry in the markets of Hong Kong. The continued presence of H9N2 influenza viruses in poultry markets in southern China increases the likelihood of avian-to-human interspecies transmission.
自1998年以来,甲型H9N2禽流感病毒已在亚洲多次引发人类感染。在此,我们报告2003年在香港有一名5岁儿童感染了H9N2流感病毒。为确定可能的感染源,对从2003年1月至10月香港家禽市场分离出的该人类毒株及其他H9N2流感病毒进行了基因和抗原特性分析。本研究结果表明,人类H9N2流感病毒A/香港/2108/03完全源自禽类,并且与香港市场家禽中传播的一些病毒密切相关。中国南方家禽市场持续存在H9N2流感病毒增加了禽传人跨物种传播的可能性。