Lee Benjamin Y, Yanamandra Krishna, Bocchini Joseph A
Department of Pediatrics, Louisiana State University Health Sciences Center, 1501 Kings Hwy, Shreveport, LA 71130, USA.
Oncol Rep. 2005 Dec;14(6):1589-92.
Based solely on clinical clues from a malnourished population, thiamin alone was intentionally and successfully injected to human cases with some tumors or masses. Two cases of submandibular gland cyst and 13 out of 15 cases of Baker's cyst were cured without recurrence for several decades. In a case with pathology-confirmed osteosarcoma, subcutaneous perfusion of thiamin HCl 300 once only reduced its circumference from 30 to 20 cm, equivalent to a reduction of 50-75% in volume, within 2 days. Current concepts on the role of thiamin in carcinogenesis are controversial. Some authors claimed that thiamin supported high rate of tumor cell survival, proliferation and chemotherapy resistance and suggested anti-thiamin therapy for cancer. On the other hand, some investigators have reported evidence of prevention of several varieties of cancers by dietary thiamin. A limited number of animal studies revealed evident relationship between thiamin deficiency and cancer development. Therefore, further study on the mechanism switching thiamin between cancer supporter and suppressor is needed.
仅基于来自营养不良人群的临床线索，单独将硫胺素有意且成功地注射到一些患有肿瘤或肿块的人类病例中。两例下颌下腺囊肿病例以及15例贝克囊肿病例中的13例被治愈，数十年未复发。在一例经病理确诊的骨肉瘤病例中，仅一次皮下灌注300毫克盐酸硫胺素，在两天内就使其周长从30厘米缩小到20厘米，相当于体积减少了50 - 75%。目前关于硫胺素在致癌作用中的作用的概念存在争议。一些作者声称硫胺素支持肿瘤细胞的高存活率、增殖率和化疗耐药性，并建议对癌症进行抗硫胺素治疗。另一方面，一些研究人员报告了饮食中硫胺素预防多种癌症的证据。有限的动物研究揭示了硫胺素缺乏与癌症发展之间的明显关系。因此，需要进一步研究硫胺素在癌症促进者和抑制者之间转换的机制。
