原发性胰腺间变性大细胞淋巴瘤，ALK阴性：一例报告
Primary pancreatic anaplastic large cell lymphoma, ALK negative: a case report.
作者信息
Savopoulos Christos-G, Tsesmeli N-E, Kaiafa G-D, Zantidis A-T, Bobos M-T, Hatzitolios A-I, Papavramidis S-T, Kostopoulos I-S
机构信息
1(st) Medical Propedeutic Department, AHEPA Hospital, Aristotle University of Thessaloniki, St. Kyriakidi 1, Thessaloniki 54636, Greece.
出版信息
World J Gastroenterol. 2005 Oct 21;11(39):6221-4. doi: 10.3748/wjg.v11.i39.6221.
We present the fourth case of a primary pancreatic anaplastic large cell lymphoma (ALCL), ALK-. An 80-year-old man was admitted to our clinic for further investigation of a fever of unknown origin. He noted anorexia, weight loss and fatigue. His laboratory tests showed anemia and a great elevation of ESR, LDH, and beta (2) microglobulin. In CT and MRI scan, a soft tissue mass in the pancreas was observed. A repeated endoscopy after his admission revealed an ulcerated mass-like deformity of the duodenal bulb. Explorative laparotomy confirmed a diffuse spread of an unresectable malignant pancreatic mass extending to the adjacent organs. Duodenal and surgical biopsies identified an ALCL of T-cell lineage, ALK-. The patient died in the Intensive Care Unit due to hemodynamic instability. Our case is the first one indicating that primary pancreatic lymphoma should be suspected in a patient with pancreatic mass and elevated serum LDH and beta(2) microglobulin.
我们报告第四例原发性胰腺间变性大细胞淋巴瘤（ALCL），ALK阴性。一名80岁男性因不明原因发热入住我院进一步检查。他有厌食、体重减轻和疲劳症状。实验室检查显示贫血，血沉、乳酸脱氢酶和β2微球蛋白显著升高。CT和MRI扫描显示胰腺有软组织肿块。入院后重复进行的内镜检查显示十二指肠球部有溃疡样肿块变形。剖腹探查证实不可切除的恶性胰腺肿块弥漫性扩散至邻近器官。十二指肠活检和手术活检确定为T细胞谱系的ALCL，ALK阴性。患者因血流动力学不稳定在重症监护病房死亡。我们的病例是首例表明，对于有胰腺肿块且血清乳酸脱氢酶和β2微球蛋白升高的患者，应怀疑原发性胰腺淋巴瘤。
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