Dal Prato Luca, Borini Andrea, Cattoli Monica, Preti Maria Serena, Serrao Lucia, Flamigni Carlo
Tecnobios Procreazione, Centre for Reproductive Health, Via Dante 15, I-40125 Bologna, Italy.
Reprod Biomed Online. 2005 Oct;11(4):452-4. doi: 10.1016/s1472-6483(10)61139-x.
Pregnancies after IVF have been reported in women aged > or =44 years, but nobody older than 45 years at oocyte retrieval delivered. We report a case of birth of a healthy child after IVF in a 46-year-old infertile woman. Ovarian stimulation was performed with clomiphene citrate, 150 mg daily for 5 days. Three oocytes were retrieved and one embryo was replaced. The patient delivered a healthy male infant after Caesarean section at 39 weeks. A successful pregnancy after IVF with homologous oocytes can be achieved in women older than 45 years. At this age IVF is not a cost-effective treatment compared with oocyte donation, but it may be offered in countries in which gamete donation is forbidden.
据报道，年龄≥44岁的女性在体外受精（IVF）后有怀孕的情况，但在取卵时年龄超过45岁的女性中，尚无分娩的报道。我们报告了一例46岁不孕女性经体外受精后分娩健康婴儿的病例。使用枸橼酸氯米芬进行卵巢刺激，每日150毫克，共5天。取出3个卵母细胞，植入1个胚胎。患者在39周时剖宫产下一名健康男婴。45岁以上女性使用同源卵母细胞进行体外受精后可成功怀孕。在这个年龄，与卵母细胞捐赠相比，体外受精不是一种性价比高的治疗方法，但在禁止配子捐赠的国家可能会提供这种治疗。
