Division of Reproductive Endocrinology, Sims IVF, Dublin, Ireland.
Reprod Biol Endocrinol. 2010 Mar 25;8:31. doi: 10.1186/1477-7827-8-31.
Premature ovarian failure (POF) remains a clinically challenging entity because in vitro fertilisation (IVF) with donor oocytes is currently the only treatment known to be effective.
A 33 year-old nulligravid patient with a normal karyotype was diagnosed with POF; she had a history of failed fertility treatments and had an elevated serum FSH (42 mIU/ml). Oocytes donated by her dizygotic twin sister were used for IVF. The donor had already completed a successful pregnancy herself and subsequently produced a total of 10 oocytes after a combined FSH/LH superovulation regime. These eggs were fertilised with sperm from the recipient's husband via intracytoplasmic injection and two fresh embryos were transferred to the recipient on day three.
A healthy twin pregnancy resulted from IVF; two boys were delivered by caesarean section at 39 weeks' gestation. Additionally, four embryos were cryopreserved for the recipient's future use. The sister-donor achieved another natural pregnancy six months after oocyte retrieval, resulting in a healthy singleton delivery.
POF is believed to affect approximately 1% of reproductive age females, and POF patients with a sister who can be an oocyte donor for IVF are rare. Most such IVF patients will conceive from treatment using oocytes from an anonymous oocyte donor. This is the first report of births following sister-donor oocyte IVF in Ireland. Indeed, while sister-donor IVF has been successfully undertaken by IVF units elsewhere, this is the only known case where oocyte donation involved twin sisters. As with all types of donor gamete therapy, pre-treatment counselling is important in the circumstance of sister oocyte donation.
卵巢早衰（POF）仍然是一个具有临床挑战性的实体，因为体外受精（IVF）用供体卵是目前已知唯一有效的治疗方法。
一名 33 岁的原发不孕患者，核型正常，被诊断为 POF；她有多次不孕治疗失败的病史，血清 FSH 升高（42 mIU/ml）。使用她的异卵双胞胎妹妹捐赠的卵母细胞进行 IVF。供体已经成功怀孕，并在 FSH/LH 超排卵方案后总共产生了 10 个卵母细胞。这些卵子通过胞浆内注射与受体丈夫的精子受精，第三天将两个新鲜胚胎移植给受体。
IVF 成功妊娠，双胞胎男孩通过剖宫产分娩，孕龄 39 周。此外，还冷冻保存了四个胚胎以备受体将来使用。供体在取卵后 6 个月自然妊娠，成功分娩了一个健康的单胎。
POF 据信影响大约 1%的育龄女性，而有姐妹可以作为 IVF 供体提供卵母细胞的 POF 患者很少见。大多数此类 IVF 患者将通过使用匿名供体卵母细胞的治疗来怀孕。这是爱尔兰首例姐妹供体卵母细胞 IVF 出生的报道。事实上，虽然其他 IVF 单位已经成功地进行了姐妹供体 IVF，但这是唯一一例涉及双胞胎姐妹的卵母细胞捐赠。与所有类型的供体配子治疗一样，在姐妹卵母细胞捐赠的情况下，预先治疗咨询很重要。
