Miyazaki Miho, Kubota Toshiaki, Kubo Michiaki, Kiyohara Yutaka, Iida Mituo, Nose Yoshiaki, Ishibashi Tatsuro
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
J Glaucoma. 2005 Dec;14(6):482-4. doi: 10.1097/01.ijg.0000185436.15675.b3.
To examine the prevalence and systemic associations of pseudoexfoliation syndrome (PXS) in a Japanese population.
In 1998, a cross-sectional population-based survey was conducted among residents of Hisayama. Of a total of 3054 residents living in Hisayama, Japan, aged 50 years or older, 1844 consented to participate in the study. Each participant underwent a comprehensive examination that included an ophthalmic examination. The presence of any pseudoexfoliation material on the iris or lens capsule was determined by slit-lamp examination. The participants were classified as having pseudoexfoliation syndrome if any pseudoexfoliation material was present in either eye. Using these cross-sectional data, logistic regression analyses were performed to determine the systemic associations of pseudoexfoliation syndrome. The following eight possible correlates were considered: age, sex, hypertension, diabetes, hyperlipidemia, current smoker, alcohol intake, and body mass index.
Among the subjects, 50 (3.4%) had pseudoexfoliation syndrome. The prevalence of pseudoexfoliation syndrome increased significantly with age. Multiple logistic regression analysis showed that age and hypertension were significantly associated with pseudoexfoliation syndrome.
The prevalence of pseudoexfoliation syndrome in a Japanese population was 3.4%, and increased with age. This study suggests that hypertension strongly correlates with pseudoexfoliation syndrome in our population-based sample of Japanese subjects aged 50 years or older.
研究日本人群中假性剥脱综合征（PXS）的患病率及其与全身因素的关联。
1998年，对久山町的居民进行了一项基于人群的横断面调查。在日本久山町居住的3054名50岁及以上居民中，1844人同意参与研究。每位参与者都接受了包括眼科检查在内的全面检查。通过裂隙灯检查确定虹膜或晶状体囊膜上是否存在任何假性剥脱物质。如果任何一只眼睛存在假性剥脱物质，则将参与者归类为患有假性剥脱综合征。利用这些横断面数据，进行逻辑回归分析以确定假性剥脱综合征与全身因素的关联。考虑了以下八个可能的相关因素：年龄、性别、高血压、糖尿病、高脂血症、当前吸烟者、饮酒量和体重指数。
在这些受试者中，50人（3.4%）患有假性剥脱综合征。假性剥脱综合征的患病率随年龄显著增加。多元逻辑回归分析表明，年龄和高血压与假性剥脱综合征显著相关。
日本人群中假性剥脱综合征的患病率为3.4%，且随年龄增加。本研究表明，在我们以人群为基础的50岁及以上日本受试者样本中，高血压与假性剥脱综合征密切相关。
