Department of Ophthalmology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Acta Ophthalmol. 2012 Sep;90(6):e470-5. doi: 10.1111/j.1755-3768.2012.02439.x. Epub 2012 May 2.
To determine the prevalence of pseudoexfoliation syndrome (PEX) in Lithuanian urban population and its association with ischaemic heart disease (IHD), arterial hypertension (AH) and diabetes mellitus (DM).
In this population-based study, 1065 participants aged 45-72 years were randomly drawn from the population register of Kaunas, Lithuania. They were classified as having PEX if any pseudoexfoliation material was determined by a slit-lamp examination in at least one eye. The data were acquired from questionnaire; register of myocardial infarction, electrocardiogram, biochemical blood analyses and blood pressure measurement were used to determine IHD, AH, DM and smoking habits. Poststratification weights based on Kaunas population sex and age distribution were applied.
Pseudoexfoliation syndrome was estimated in 9% of a population. The AH rate was higher in PEX subjects than in non-PEX subjects (p=0.017) and the rates of IHD, DM and cholesterol levels did not differ statistically significantly. Chi-square linear-by-linear association test found higher AH rate in unilateral PEX subjects and even higher AH rate in bilateral PEX subjects than in non-PEX subjects (p=0.014). Pseudoexfoliation syndrome increased odds for AH by 1.8 times (p=0.021). Median of systolic blood pressure was higher in the PEX group than in non-PEX group (p=0.04). But all associations could not be confirmed after adjusting for age. Smoking duration increased age-adjusted odds for PEX. Pseudoexfoliation syndrome did not increase risk for IHD, AH or DM.
Pseudoexfoliation syndrome prevalence is high in Lithuania. No clear PEX association with IHD, AH and DM was proven after controlling for effect of age.
确定立陶宛城市人口中假性剥脱综合征（PEX）的患病率及其与缺血性心脏病（IHD）、动脉高血压（AH）和糖尿病（DM）的关系。
在这项基于人群的研究中，从立陶宛考纳斯的人口登记册中随机抽取了 1065 名年龄在 45-72 岁的参与者。如果在至少一只眼中通过裂隙灯检查确定存在任何假性剥脱物质，则将其归类为 PEX。数据来自问卷调查；心肌梗死登记、心电图、生化血液分析和血压测量用于确定 IHD、AH、DM 和吸烟习惯。应用基于考纳斯人口性别和年龄分布的后分层权重。
估计人群中有 9%的人患有 PEX。PEX 受试者的 AH 发生率高于非 PEX 受试者（p=0.017），而 IHD、DM 和胆固醇水平的发生率无统计学差异。卡方线性线性关联检验发现单侧 PEX 受试者的 AH 发生率更高，双侧 PEX 受试者的 AH 发生率甚至更高，而非 PEX 受试者（p=0.014）。PEX 使 AH 的发生风险增加了 1.8 倍（p=0.021）。PEX 组的收缩压中位数高于非 PEX 组（p=0.04）。但在调整年龄后，所有关联均无法得到证实。吸烟时间的延长增加了 PEX 的年龄调整优势比。PEX 并未增加 IHD、AH 或 DM 的风险。
立陶宛 PEX 的患病率较高。在控制年龄影响后，未证明 PEX 与 IHD、AH 和 DM 之间存在明确的关系。
