Leung P Y, Dunham W B, Tsao C S
Linus Pauling Institute of Science and Medicine, Palo Alto, California 94306.
In Vivo. 1992 Jan-Feb;6(1):33-40.
The growth of human lung carcinoma xenografts implanted beneath the renal capsule of immunocompetent mice was investigated (the six-day subrenal capsule assay) by using combinations of ascorbic acid and cupric ions. A maximum suppression of growth of this human lung tumor, LX-1, was observed at an estimated consumption level by the mice of 6 to 8 g ascorbic acid and 2 to 5 mg cupric ions per day per kg body weight. The data suggest that more than one oxidative or degradative product of ascorbic acid or of some copper compounds may be responsible for the observed antitumor activities, and that the chemotherapeutic effect is being produced at some stoichiometric ratios of ascorbic acid to cupric ions. When such a combination of the two substances was consumed by the mice, optimal therapeutic effect was exerted on the implanted xenografts.
通过使用抗坏血酸和铜离子的组合，研究了植入免疫活性小鼠肾包膜下的人肺癌异种移植瘤的生长情况（六天肾包膜下试验）。在估计小鼠每天每千克体重消耗6至8克抗坏血酸和2至5毫克铜离子的水平下，观察到这种人肺肿瘤LX-1的生长受到最大抑制。数据表明，抗坏血酸或某些铜化合物的一种以上氧化或降解产物可能是观察到的抗肿瘤活性的原因，并且化疗效果是在抗坏血酸与铜离子的某些化学计量比下产生的。当小鼠消耗这两种物质的这种组合时，对植入的异种移植瘤产生了最佳治疗效果。
