Tsao C S
Linus Pauling Institute of Science and Medicine, Palo Alto, CA 94306.
Am J Clin Nutr. 1991 Dec;54(6 Suppl):1274S-1280S. doi: 10.1093/ajcn/54.6.1274s.
The effect of ascorbic acid on the growth of a human mammary tumor in mice has been investigated using the 6-d subrenal capsule assay method. The results indicated that ascorbic acid administered in the drinking water significantly inhibited the growth of the tumor fragments implanted beneath the renal capsule of mice. Administration of a mixture of ascorbic acid and cupric sulfate orally or intraperitoneally significantly inhibited tumor growth in these mice, whereas neither alone was effective. These results support the hypothesis that certain oxidation or degradation products of ascorbic acid were active antineoplastic agents for the human mammary tumor studied. The activity of D-isoascorbic acid, an isomer of ascorbic acid, was similar to that of ascorbic acid. This suggests that the antitumor activity of ascorbic acid was not due to the metabolism of ascorbic acid as a vitamin, but due to its chemical properties.
已使用6天肾包膜下试验方法研究了抗坏血酸对小鼠人乳腺肿瘤生长的影响。结果表明，饮用水中添加抗坏血酸可显著抑制植入小鼠肾包膜下的肿瘤碎片的生长。口服或腹腔注射抗坏血酸与硫酸铜的混合物可显著抑制这些小鼠的肿瘤生长，而单独使用两者均无效。这些结果支持了这样的假设，即抗坏血酸的某些氧化或降解产物是所研究的人乳腺肿瘤的活性抗肿瘤剂。抗坏血酸的异构体D-异抗坏血酸的活性与抗坏血酸相似。这表明抗坏血酸的抗肿瘤活性不是由于其作为维生素的代谢，而是由于其化学性质。
