Tets V V, Zaslavskaia N V
Zh Mikrobiol Epidemiol Immunobiol. 2005 Sep-Oct(5):24-6.
Bacteria can form different types of communities, united by common notion: biofilms. The aim of the present study was to determine the capacity of different antibiotics to penetrate into biofilms and act on unrelated bacteria. The study revealed that the formation of barriers between the community and the environment on artificial biofilms occurred in all strains of unrelated Gram-positive and Gram-negative bacteria used in this investigation. The capacity of antibiotics to penetrate into biofilms varied in different strains of the same species. For certain antibiotics similarity in their penetrating capacity was found to exist with respect to biofilms of unrelated bacteria. The penetration of antibiotics into mixed biofilms depended on the strain which determined its minimal value, so that the protection of one microorganism by another was thus observed. The method for the evaluation of the effectiveness of antibiotic penetration into bacterial biofilms, suitable for use in bacteriological laboratories, is proposed.
细菌可以形成不同类型的群落，这些群落由一个共同的概念统一起来：生物膜。本研究的目的是确定不同抗生素渗透到生物膜中并作用于不相关细菌的能力。研究表明，在本研究中使用的所有不相关革兰氏阳性和革兰氏阴性细菌菌株中，人工生物膜上的群落与环境之间都会形成屏障。抗生素渗透到生物膜中的能力在同一物种的不同菌株中有所不同。对于某些抗生素，发现它们在渗透能力方面与不相关细菌的生物膜存在相似性。抗生素渗透到混合生物膜中的情况取决于决定其最小值的菌株，因此观察到一种微生物对另一种微生物的保护作用。本文提出了一种适用于细菌学实验室的评估抗生素渗透细菌生物膜有效性的方法。
