Kuzniar Piotr, Jastrzebska Emilia, Ploski Rafal
Human Molecular Genetics Laboratory of Department of Pediatrics, Medical University of Warsaw ul. Oczki 1 02-007 Warsaw, Poland.
Forensic Sci Int. 2006 Jun 2;159(2-3):258-60. doi: 10.1016/j.forsciint.2005.05.009. Epub 2005 Nov 8.
The D7S1517, D3S1744, D12S391, D2S1360, D6S474, D8S1132, D5S2500, D10S2325 and D4S236613 are STR loci potentially useful for forensic purposes whose analysis has recently become facilitated by availability of a commercial kit. The purpose of the study was to evaluate the usefulness of these loci for forensic identification in a population of Central Poland. The distribution of alleles of the nine STRs was determined in sample of 353 unrelated individuals born in Central Poland and indices of forensic informativeness were calculated. The studied loci were highly informative and did not show departures from Hardy-Weinberg equilibrium. For the loci located on the same chromosomes (D2S1360, D3S1744 D4S2366, D5S2500, D7S1517, D8S1132, D12S391) as other loci commonly used for identification purposes (TPOX, D2S1338, D3S1358, FGA, D5S818, D7S820, D8S1179 and D12S391) appropriate pairwise analysis of linkage disequilibrium was performed. In all cases no statistically significant deviation from independence was found. We conclude that the studied STRs are informative and, when necessary, can be used to extend the results obtained with other STRs commonly analyzed for identification purposes, in particular the CODIS set.
D7S1517、D3S1744、D12S391、D2S1360、D6S474、D8S1132、D5S2500、D10S2325和D4S236613是可能用于法医鉴定目的的STR基因座，最近由于一种商用试剂盒的出现，对其分析变得更加便利。本研究的目的是评估这些基因座在波兰中部人群法医鉴定中的实用性。在353名出生于波兰中部的无关个体样本中确定了9个STR的等位基因分布，并计算了法医信息指数。所研究的基因座具有高度信息性，且未显示偏离哈迪-温伯格平衡。对于与其他常用于鉴定目的的基因座（TPOX、D2S1338、D3S1358、FGA、D5S818、D7S820、D8S1179和D12S391）位于相同染色体上的基因座（D2S1360、D3S1744、D4S2366、D5S2500、D7S1517、D8S1132、D12S391），进行了适当的连锁不平衡成对分析。在所有情况下，均未发现与独立性有统计学上的显著偏差。我们得出结论，所研究的STR具有信息性，并且在必要时可用于扩展通过其他常用于鉴定目的的STR，特别是联合DNA索引系统（CODIS）组所获得的结果。
