Ro Y, Muramatsu T, Shima K, Yajima Y, Shibahara T, Noma H, Shimono M
Department of Oral and Maxillofacial Surgery, Tokyo Dental College, 1-2-2, Masago, Mihama-ku, Chiba 261-8502, Japan.
Int J Oral Maxillofac Surg. 2006 Mar;35(3):252-7. doi: 10.1016/j.ijom.2005.06.020. Epub 2005 Nov 8.
We examined expression of syndecan-1 in squamous cell carcinoma (SCC) of tongue using immunohistochemistry. Forty-three cases of SCC arising in lateral border of tongue were investigated. From the immunohistochemical staining pattern, the cases were divided into two groups based on expression of syndecan-1 at the supra-peripheral cells of the tumor nest: Group A, completely or mainly positive; Group B, sporadically positive or negative. Most poorly differentiated SCC cases were classified into Group B (81.8%). The number of Group B cases in T1-2 was different from that in T3-4. The number of cases where syndecan-1 expression was reduced was much greater in T3-4, and represented the majority of Group B (86.7%). More than 80% of Grade 4D cases were in Group B (83.3%) based on the Yamamoto-Kohama criteria. These results indicate that reduction of syndecan-1 correlates to histological grade, tumor size and mode of invasion in tongue SCC.
我们采用免疫组织化学方法检测了syndecan-1在舌鳞状细胞癌（SCC）中的表达。对43例发生于舌外侧缘的SCC病例进行了研究。根据肿瘤巢外周细胞中syndecan-1的表达情况，通过免疫组织化学染色模式将病例分为两组：A组，完全或主要为阳性；B组，散在阳性或阴性。大多数低分化SCC病例被归类为B组（81.8%）。T1-2期B组病例数与T3-4期不同。T3-4期syndecan-1表达降低的病例数更多，占B组的大多数（86.7%）。根据山本-小滨标准，超过80%的4D级病例属于B组（83.3%）。这些结果表明，syndecan-1的降低与舌SCC的组织学分级、肿瘤大小和浸润方式相关。
