Kurokawa Hideo, Zhang Min, Matsumoto Shinobu, Yamashita Yoshihiro, Tanaka Toshiko, Takamori Koichi, Igawa Kaori, Yoshida Maho, Fukuyama Hiroshi, Takahashi Tetsu, Sakoda Sumio
Department of Oral and Maxillofacial Surgery, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan.
J Oral Pathol Med. 2006 May;35(5):301-6. doi: 10.1111/j.1600-0714.2006.00412.x.
Although many histopathological characteristics of oral squamous cell carcinoma (O-SCC) have been identified as prognostic factors, no factor is completely accurate and unequivocal. This study evaluated the association between the loss of syndecan-1 expression and the histological grade of malignancy at the deep invasive front in O-SCC.
The expression of syndecan-1 at the invasive tumor front of O-SCC was examined immunohistochemically using archived tissue from 72 cases. The mean age of the patients was 62.5 years (range: 23-90 years) and the male-female ratio was 1.3:1 (41 men, 31 women). There were 26, 24, 11, and 11 cases classified as stages I-IV respectively. The correlation between the intensity of syndecan-1 immunostaining and the clinicopathological factors, especially the histological grade of malignancy at the deep invasive front (invasive front grade) was analyzed.
Of the 72 cases, seven (9.7%), 29 (40.3%), 36 (50.0%) showed strong, intermediate, and weak or negative syndecan-1 staining respectively. There were significant differences between syndecan-1 expression and prognosis, differentiation, and pattern of invasion at the deep invasive front. Moreover, the invasive front grade scores, based on the intensity of syndecan-1 staining, were 5.6 +/- 1.0, 8.0 +/- 2.1, and 10.2 +/- 2.3 points with strong, intermediate, and weak or negative intensity respectively; and the difference was significant (P < 0.0001). Patients with intermediate or strong intensity for syndecan-1 had significantly better prognoses than did those with negative or weak intensity (P = 0.0138).
This study demonstrated that the reduced expression of syndecan-1 seems to be a useful marker of histological malignancy at the deep tumor invasive front and may be a useful prognostic factor in O-SCC.
尽管口腔鳞状细胞癌（O-SCC）的许多组织病理学特征已被确定为预后因素，但没有一个因素是完全准确和明确的。本研究评估了syndecan-1表达缺失与O-SCC深层浸润前沿恶性组织学分级之间的关联。
使用72例存档组织，通过免疫组织化学检查O-SCC浸润肿瘤前沿的syndecan-1表达。患者的平均年龄为62.5岁（范围：23 - 90岁），男女比例为1.3:1（41名男性，31名女性）。分别有26、24、11和11例被分类为I - IV期。分析syndecan-1免疫染色强度与临床病理因素之间的相关性，特别是深层浸润前沿的恶性组织学分级（浸润前沿分级）。
在72例病例中，分别有7例（9.7%）、29例（40.3%）、36例（50.0%）显示syndecan-1染色强、中等、弱或阴性。syndecan-1表达与预后、分化以及深层浸润前沿的浸润模式之间存在显著差异。此外，基于syndecan-1染色强度的浸润前沿分级分数分别为强、中等、弱或阴性强度时为5.6 +/- 1.0、8.0 +/- 2.1和10.2 +/- 2.3分；差异具有统计学意义（P < 0.0001）。syndecan-1强度为中等或强的患者预后明显优于阴性或弱强度的患者（P = 0.0138）。
本研究表明，syndecan-1表达降低似乎是肿瘤深层浸润前沿组织学恶性程度的一个有用标志物，可能是O-SCC的一个有用预后因素。
