微纳加工形式的DNA分析

DNA analysis in microfabricated formats.

作者信息

Abramowitz S

机构信息

Advanced Technology Program, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.

出版信息

Biomed Microdevices. 1999;1(2):107-12. doi: 10.1023/A:1009992306940.

DOI:10.1023/A:1009992306940

PMID:16281110

Abstract

The use of microfabricated DNA analysis tools utilizing microfluidics will provide the next generation of inexpensive DNA diagnostics. It will also provide methodologies to measure gene expression in a massively parallel manner, eventually providing the methodologies to measure most or all the human genes of significance on a single chip. These technologies, including PCR analysis, electrophoresis and gene chips are described using examples from the archival literature.

摘要

利用微流体技术的微型制造DNA分析工具的使用将提供下一代廉价的DNA诊断方法。它还将提供以大规模并行方式测量基因表达的方法，最终提供在单个芯片上测量大多数或所有重要人类基因的方法。这些技术，包括PCR分析、电泳和基因芯片，将通过来自存档文献的实例进行描述。