血小板活化因子（PAF）通过增强对组胺的反应，在豚鼠的速发型哮喘反应中起重要作用。
Platelet-activating factor (PAF) plays an important role in the immediate asthmatic response in guinea-pig by augmenting the response to histamine.
作者信息
Morooka S, Uchida M, Imanishi N
机构信息
Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd., Osaka, Japan.
出版信息
Br J Pharmacol. 1992 Mar;105(3):756-62. doi: 10.1111/j.1476-5381.1992.tb09051.x.
Abstract
- To investigate the role of platelet activating factor (PAF) in the immediate asthmatic response, we examined the bronchial reactivity to histamine after administration of PAF to guinea-pigs or antigen challenge to passively sensitized guinea-pigs. 2. A bolus injection of PAF (20-40 ng kg-1), which did not cause a significant increase in intrathoracic pressure (ITP), augmented the bronchial response to histamine almost 8 fold. This airway hyperreactivity was observed even 1 min after PAF treatment. 3. A subthreshold dose of antigen (0.01 mg kg-1, i.v.) also provoked hyperreactivity to histamine, which became significant 6 and 11 min after the antigen treatment. 4. The specific PAF-antagonists, SM-10661 and CV-6209 (i.v.) dose-dependently inhibited both PAF- and antigen-induced airway hyperreactivities to histamine. 5. These results suggest that PAF plays an important role in antigen-induced acute airway responses by augmenting the activities of spasmogens.
摘要
- 为研究血小板活化因子（PAF）在哮喘速发反应中的作用，我们对豚鼠给予PAF或对被动致敏豚鼠进行抗原激发后，检测了其对组胺的支气管反应性。2. 一次推注PAF（20 - 40 ng kg-1），未引起胸内压（ITP）显著升高，却使支气管对组胺的反应增强近8倍。PAF处理后1分钟即可观察到这种气道高反应性。3. 亚阈值剂量的抗原（0.01 mg kg-1，静脉注射）也可引发对组胺的高反应性，在抗原处理后6分钟和11分钟时变得显著。4. 特异性PAF拮抗剂SM - 10661和CV - 6209（静脉注射）剂量依赖性地抑制PAF和抗原诱导的气道对组胺的高反应性。5. 这些结果表明，PAF通过增强致痉物质的活性，在抗原诱导的急性气道反应中起重要作用。
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