Fahey Tom, Schroeder Knut, Ebrahim Shah
University of Dundee, Scotland.
Br J Gen Pract. 2005 Nov;55(520):875-82.
The optimal way in which to organise and deliver care to patients with hypertension has not been clearly identified.
To determine the effectiveness of educational and organisational strategies used to improve control of blood pressure.
Systematic review of randomised controlled trials (RCTs).
Quantitative pooling of RCT data on patients with hypertension that evaluated the following interventions: (1) self monitoring, (2) educational interventions directed to the patient, (3) educational interventions directed to the health professional, (4) health professional (nurse or pharmacist) led care, (5) organizational interventions that aimed to improve the delivery of care, (6) appointment reminder systems.
Fifty-six RCTs met our inclusion criteria. The methodological quality of included studies was variable. An organised system of regular review allied to vigorous antihypertensive drug therapy was shown to reduce blood pressure (weighted mean difference -8.2/-4.2mmHg, -11.7/-6.5mmHg, -10.6/-7.6mmHg for three strata of entry blood pressure) and all-cause mortality at 5 years follow-up (6.4% versus 7.8%, difference 1.4%) in a single large RCT (the Hypertension Detection and Follow-up study). Other interventions had variable effects. Self-monitoring was associated with moderate net reduction in diastolic blood pressure, weighted mean difference (WMD): -2.03 mmHg, 95% confidence interval (CI) = -2.7 to -1.4 mmHg. Educational interventions directed towards physicians were associated with small reductions in systolic blood pressure (WMD) -2.0mmHg, 95% CI = -3.5 to -0.6mmHg and diastolic blood pressure (WMD) -0.4mmHg, 95% CI -1.1 to 0.3mmHg.
General practices and community-based clinics need to have an organised system of regular follow-up and review of their hypertensive patients. Antihypertensive drug therapy should be implemented by means of a vigorous stepped care approach when patients do not reach target blood pressure levels. These findings have important implications for recommendations concerning implementation of structured delivery of care in hypertension guidelines.
尚未明确确定为高血压患者组织和提供护理的最佳方式。
确定用于改善血压控制的教育和组织策略的有效性。
随机对照试验(RCT)的系统评价。
对评估以下干预措施的高血压患者RCT数据进行定量汇总:(1)自我监测;(2)针对患者的教育干预;(3)针对卫生专业人员的教育干预;(4)卫生专业人员(护士或药剂师)主导的护理;(5)旨在改善护理提供的组织干预;(6)预约提醒系统。
56项RCT符合我们的纳入标准。纳入研究的方法学质量各不相同。在一项大型RCT(高血压检测与随访研究)中,一个与积极的抗高血压药物治疗相结合的有组织的定期复查系统显示可降低血压(三个血压分层的加权平均差为-8.2/-4. mmHg、-11.7/-6.5 mmHg、-10.6/-7.6 mmHg)以及5年随访时的全因死亡率(6.4%对7.8%,差值1.4%)。其他干预措施效果各异。自我监测与舒张压的适度净降低相关,加权平均差(WMD):-2.03 mmHg,95%置信区间(CI)=-2.7至-1.4 mmHg。针对医生的教育干预与收缩压的小幅降低(WMD)-2.0 mmHg,95% CI=-3.5至-0.6 mmHg以及舒张压的降低(WMD)-0.4 mmHg,95% CI=-1.1至-0.3 mmHg相关。
全科医疗和社区诊所需要有一个针对高血压患者的有组织的定期随访和复查系统。当患者未达到目标血压水平时,应通过积极的阶梯式护理方法实施抗高血压药物治疗。这些发现对高血压指南中关于结构化护理实施的建议具有重要意义。