Schumacher H R, Szekely I E, Fisher D R
Am J Pathol. 1975 Jan;78(1):49-58.
Quantitative and qualitative electron microscopic studies were performed on the mitochondria of leukemic lymphoblasts in 6 patients with acute lymphoblastic leukemia. Similar studies were performed on lymphoblasts from lymph nodes obtained from 10 surgical patients without nodal diseases. Significant quantitative differences between normal and leukemic mitochondria were not observed except for a difference in mitochondrial area per cell (P less than 0.05). This was not significant lacking, qualitative diffecrences were observed. These abnormalities included rare giant mitochondria, disrupted mitochondria with virus-like particles, smaller granules in greater abundance, mitochondrial DNA, and contact between the mitochondrion and nucleus during interphase. Fifty-three percent of the leukemic lymphoblasts contained polyribosomes, as compared to 25% of the normal lymphoblasts. The cells with the polyribosomes contained the giant mitochondria. The leukemic lymphoblasts had an appearance similar to transformed lymphocytes resulting from an immunologic stimulus. This suggests that acute lymphoblastic leukemia may be a disease which is associated with an immunologic response. From the available ultrastructural and biochemical data, it would seem that the leukemic lymphoblast is a product of an abnormal metabolism which affects its ability to differentiate. These ultrastructural findings seem to indicate the need for biochemical investigation of leukemic mitochondria. (Am J Pathol 78:49-58, 1975
对6例急性淋巴细胞白血病患者的白血病淋巴母细胞线粒体进行了定量和定性电子显微镜研究。对10例无淋巴结疾病的手术患者淋巴结中的淋巴母细胞进行了类似研究。除了每个细胞的线粒体面积存在差异（P小于0.05）外，未观察到正常线粒体与白血病线粒体之间存在显著的定量差异。这一差异并不显著，未观察到定性差异。这些异常包括罕见的巨型线粒体、带有病毒样颗粒的破碎线粒体、数量更多的较小颗粒、线粒体DNA以及间期线粒体与细胞核之间的接触。53%的白血病淋巴母细胞含有多核糖体，而正常淋巴母细胞中这一比例为25%。含有多核糖体的细胞含有巨型线粒体。白血病淋巴母细胞的外观类似于由免疫刺激产生的转化淋巴细胞。这表明急性淋巴细胞白血病可能是一种与免疫反应相关的疾病。从现有的超微结构和生化数据来看，白血病淋巴母细胞似乎是异常代谢的产物，这种异常代谢影响了其分化能力。这些超微结构发现似乎表明有必要对白血病线粒体进行生化研究。（《美国病理学杂志》78:49 - 58，1975年）
