Rosen Michael R, Cohen Ira S
Department of Pharmacology and Pediatrics, Center for Molecular Therapeutics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.
J Physiol. 2006 Jan 15;570(Pt 2):209-18. doi: 10.1113/jphysiol.2005.097873. Epub 2005 Nov 10.
'Cardiac memory' describes an electrocardiographic T wave vector change, recorded during normal sinus rhythm that reflects the QRS complex vector during prior periods of ventricular pacing or arrhythmia. In this brief review we consider the mechanisms responsible for cardiac memory, which offer a unique window for relating molecular determinants of repolarization to their expression in the function of ion channels and in the electrophysiology of the heart. Understanding the steps that translate the molecular mechanisms for memory into clinical expression in this relatively straightforward model facilitates our comprehension of the complex pathways that order normal cardiac repolarization and repolarization changes.
“心脏记忆”描述的是一种心电图T波向量变化，在正常窦性心律期间记录到，它反映了先前心室起搏或心律失常期间的QRS波群向量。在这篇简短的综述中，我们探讨了心脏记忆的形成机制，这些机制为将复极化的分子决定因素与其在离子通道功能和心脏电生理学中的表达联系起来提供了一个独特的窗口。理解在这个相对简单的模型中，将记忆的分子机制转化为临床表型的步骤，有助于我们理解调控正常心脏复极化及复极化变化的复杂途径。
