Sandor F, Buc M
Department of Immunology, Comenius University School of Medicine, Sasinkova, Bratislava, Slovakia.
Folia Biol (Praha). 2005;51(5):148-57.
The innate immune system senses invading microorganisms by a phylogenetically conserved family of proteins PRRs of which TLRs are ones of the most important. There are at least 10 different TLRs in humans and 11 in mice. They have in the course of evolution specialized for the recognition of conserved structures among microorganisms called PAMPs. Activation of TLRs results in induction of innate immunity mechanisms as well in development of antigen-specific adaptive immune responses, thus bridging innate and adaptive immunity.
固有免疫系统通过一个在系统发育上保守的蛋白质家族——模式识别受体（PRR）来感知入侵的微生物，其中Toll样受体（TLR）是最重要的一类。人类至少有10种不同的TLR，小鼠有11种。在进化过程中，它们专门用于识别微生物中被称为病原体相关分子模式（PAMP）的保守结构。TLR的激活不仅会诱导固有免疫机制，还会促进抗原特异性适应性免疫反应的发展，从而在固有免疫和适应性免疫之间架起桥梁。
