南非GB病毒C分离株：1型和5型分离株与HIV之间的相互作用

South African GB virus C isolates: interactions between genotypes 1 and 5 isolates and HIV.

作者信息

Xiang Jinhua, Sathar M Aslam, McLinden James H, Klinzman Donna, Chang Qing, Stapleton Jack T

机构信息

Research and Medical Service, Iowa City VA Medical Center, Iowa City, 52242, USA.

出版信息

J Infect Dis. 2005 Dec 15;192(12):2147-51. doi: 10.1086/498170. Epub 2005 Nov 11.

DOI:10.1086/498170

PMID:16288381

Abstract

GB virus C (GBV-C) is a common, apparently nonpathogenic human flavivirus that has been associated in some studies with prolonged survival in human immunodeficiency virus (HIV)-positive persons. There are 5 distinct GBV-C genotypes localized to specific geographic regions, and genotype 2 has been previously shown to inhibit HIV replication in vitro in lymphocyte cultures. We identified GBV-C virus isolates representing genotypes 1, 2, and 5 in samples from South African blood donors. GBV-C genotype 1 and 5 isolates replicated in lymphocyte culture, inhibited X4 and R5 HIV-1 isolates, and induced RANTES and stromal-derived factor-1 chemokines in vitro. Thus, African GBV-C genotypes can inhibit HIV replication in vitro.

摘要

GB病毒C（GBV-C）是一种常见的、明显无致病性的人类黄病毒，在一些研究中，它与人类免疫缺陷病毒（HIV）阳性者的生存期延长有关。有5种不同的GBV-C基因型定位于特定的地理区域，先前已表明2型基因型在淋巴细胞培养中可在体外抑制HIV复制。我们在南非献血者的样本中鉴定出代表1型、2型和5型基因型的GBV-C病毒分离株。GBV-C 1型和5型分离株在淋巴细胞培养中复制，抑制X4和R5 HIV-1分离株，并在体外诱导调节激活正常T细胞表达和分泌的趋化因子（RANTES）和基质细胞衍生因子-1趋化因子。因此，非洲GBV-C基因型可在体外抑制HIV复制。