Lantéri-Minet Michel, Radat Françoise, Chautard Marie-Hélène, Lucas Christian
Department of Evaluation and Treatment of Pain, University Teaching Hospital, Hospital Pasteur, 06602 Nice, France Department of Treatment of Chronic Pain Patients, Pellegrin University Teaching Hospital, 33000 Bordeaux, France AstraZeneca France, Rueil-Malmaison, France Neurological Clinic, Hospital Salengro, Lille, France.
Pain. 2005 Dec 5;118(3):319-326. doi: 10.1016/j.pain.2005.09.010. Epub 2005 Nov 14.
Anxiety and depression are reported to be frequently associated with migraine but how they impact on migraine-related disability, migraine subjects' quality of life, and medical and therapeutic management of migraine attacks has not been investigated. FRAMIG 3 is a nation-wide population-based postal survey carried out in France according to the 2004 international classification of headache disorders. Subjects who had had migraine attacks during the last 3 months (subjects with 'active migraine', N = 1957) were analysed for migraine-related disability (MIDAS score), quality of life (SF-12 questionnaire), and anxiety and depression (Hospital Anxiety and Depression Scale [HADS]) in comparison with non-migraine subjects (N = 8287). Survey results indicate that 50.6% of subjects with active migraine were anxious and/or depressive (28.0% had anxiety alone, 3.5% depression alone, and 19.1% both anxiety and depression; P < or = 0.01 versus non-migraine subjects for anxiety alone and combined anxiety and depression, NS for depression alone). Although, migraine-associated anxiety and depression do not appear to influence the drugs taken by migraine subjects for the acute treatment of migraine attacks, perceived treatment efficacy and satisfaction with treatment are lower in subjects with anxiety alone or combined with depression than in subjects with neither anxiety nor depression. Anxiety and depression should be systemically looked for and cared for in subjects consulting for migraine.
据报道，焦虑和抑郁与偏头痛经常相关，但它们如何影响偏头痛相关的残疾、偏头痛患者的生活质量以及偏头痛发作的医学和治疗管理尚未得到研究。FRAMIG 3是一项在法国根据2004年国际头痛疾病分类进行的全国性基于人群的邮政调查。对在过去3个月内有偏头痛发作的受试者（“活动性偏头痛”受试者，N = 1957）进行了偏头痛相关残疾（MIDAS评分）、生活质量（SF - 12问卷）以及焦虑和抑郁（医院焦虑抑郁量表[HADS]）的分析，并与非偏头痛受试者（N = 8287）进行比较。调查结果表明，50.6%的活动性偏头痛受试者存在焦虑和/或抑郁（28.0%仅患有焦虑，3.5%仅患有抑郁，19.1%同时患有焦虑和抑郁；仅焦虑以及焦虑和抑郁合并情况与非偏头痛受试者相比P≤0.01，仅抑郁情况无统计学差异）。尽管偏头痛相关的焦虑和抑郁似乎不影响偏头痛患者用于急性治疗偏头痛发作所服用的药物，但仅患有焦虑或合并抑郁的受试者对治疗效果的感知和对治疗的满意度低于既无焦虑也无抑郁的受试者。对于因偏头痛前来咨询的患者，应系统地排查并关注焦虑和抑郁情况。
