Cahan C, Decker M J, Arnold J L, Washington L H, Veldhuis J D, Goldwasser E, Strohl K P
Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
J Appl Physiol (1985). 1992 Jun;72(6):2112-7. doi: 10.1152/jappl.1992.72.6.2112.
We measured arterial oxygen saturation (SaO2) and serum erythropoietin (EPO) levels in patients with obstructive sleep apnea syndrome (OSAS) and in healthy subjects. SaO2 profile was analyzed as the cumulative distribution of SaO2 over time. OSAS patients spent 25.5 +/- 30.9% (SD) of the time at SaO2 of less than 88% vs. 0.64 +/- 1.6% in healthy subjects (P less than 0.05) and had 59 +/- 25 desaturations (greater than 4%) per hour vs. less than 5 per hour in healthy subjects (P less than 0.05). EPO measurements (radioimmunoassay) were made in blood samples withdrawn every 1 or 2 h over a 24-h period. The mean EPO concentration was higher (P less than 0.05) for OSAS patients (45 +/- 33 mU/ml) than for normal subjects (17 +/- 8 mU/ml). There was a significant variability in EPO values over the 24-h period. To analyze the EPO pattern over 24 h, EPO time series were fit to a general cosine function. Data from normal subjects conformed to a cosine function with an amplitude of 3.5 +/- 2.1 (CV of 60%) and an acrophase of 1,000 +/- 184 min after 0800 (CV of 18%), indicating a zenith about 1 A.M. and a nadir around 1 P.M. Data from OSAS subjects fit a similar cosine function with an amplitude of 19.9 +/- 41.0 (CV of 206%) and acrophase of 582 +/- 408 min (CV of 70%), indicating a greater variability in the magnitude and the timing of peak serum EPO levels.(ABSTRACT TRUNCATED AT 250 WORDS)
我们测量了阻塞性睡眠呼吸暂停综合征（OSAS）患者和健康受试者的动脉血氧饱和度（SaO2）及血清促红细胞生成素（EPO）水平。将SaO2曲线分析为SaO2随时间的累积分布。OSAS患者在SaO2低于88%的时间占25.5±30.9%（标准差），而健康受试者为0.64±1.6%（P<0.05），且OSAS患者每小时有59±25次血氧饱和度下降（大于4%），健康受试者每小时少于5次（P<0.05）。在24小时内，每隔1或2小时采集血样进行EPO检测（放射免疫测定）。OSAS患者的平均EPO浓度（45±33 mU/ml）高于正常受试者（17±8 mU/ml）（P<0.05）。24小时内EPO值存在显著变异性。为分析24小时内的EPO模式，将EPO时间序列拟合为一般余弦函数。正常受试者的数据符合余弦函数，振幅为3.5±2.1（变异系数为60%），在08:00后1000±184分钟达到峰值相位（变异系数为18%），表明凌晨1点左右达到峰值，下午1点左右达到谷值。OSAS受试者的数据拟合类似的余弦函数，振幅为19.9±41.0（变异系数为206%），峰值相位为582±408分钟（变异系数为70%），表明血清EPO水平峰值的幅度和时间变异性更大。（摘要截短至250字）
