Yang Jian, Webb Antonio R, Pickerill Samuel J, Hageman Gretchen, Ameer Guillermo A
Biomedical Engineering Department, Northwestern University, Evanston, IL 60208, USA.
Biomaterials. 2006 Mar;27(9):1889-98. doi: 10.1016/j.biomaterials.2005.05.106. Epub 2005 Nov 15.
Herein, we report the synthesis and evaluation of a novel family of biodegradable and elastomeric polyesters, poly(diol citrates). Poly(diol citrates) were synthesized by reacting citric acid with various diols to form a covalent cross-linked network via a polycondensation reaction without using exogenous catalysts. The tensile strength of poly(diol citrates) were as high as 11.15+/-2.62 MPa and Young's modulus ranged from 1.60+/-0.05 to 13.98+/-3.05 MPa under the synthesis conditions that were investigated. Elongation was as high as 502+/-16%. No permanent deformation was found during mechanical tests. The equilibrium water-in-air contact angles of measured poly(diol citrates) films ranged from 15 degrees to 53 degrees . The mechanical properties, degradation and surface characteristics of poly(diol citrates) could be controlled by choosing different diols as well as by controlling the cross-link density of the polyester network. Various types of poly(diol citrate) scaffolds were fabricated to demonstrate their processing potential. These scaffolds were soft and could recover from deformation. In vitro and in vivo evaluation using cell culture and subcutaneous implantation, respectively, confirmed cell and tissue compatibility. The introduction of poly(diol citrates) will expand the repertoire of currently available biodegradable polymeric elastomers and should help meet the requirements of tissue engineering applications.
在此，我们报告了一类新型可生物降解弹性聚酯——聚柠檬酸二醇酯的合成与评估。聚柠檬酸二醇酯是通过柠檬酸与各种二醇反应，在不使用外源催化剂的情况下经缩聚反应形成共价交联网络而合成的。在所研究的合成条件下，聚柠檬酸二醇酯的拉伸强度高达11.15±2.62 MPa，杨氏模量在1.60±0.05至13.98±3.05 MPa之间。伸长率高达502±16%。在力学测试过程中未发现永久变形。所测聚柠檬酸二醇酯薄膜在空气中的平衡水接触角在15°至53°之间。通过选择不同的二醇以及控制聚酯网络的交联密度，可以控制聚柠檬酸二醇酯的力学性能、降解和表面特性。制备了各种类型的聚柠檬酸二醇酯支架以展示其加工潜力。这些支架质地柔软，能从变形中恢复。分别使用细胞培养和皮下植入进行的体外和体内评估证实了细胞和组织相容性。聚柠檬酸二醇酯的引入将扩大目前可用的可生物降解聚合物弹性体的种类，应有助于满足组织工程应用的需求。
