van den Berg M M, van Rossum C H, de Lorijn F, Reitsma J B, Di Lorenzo C, Benninga M A
Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital, Amsterdam, The Netherlands.
J Pediatr. 2005 Nov;147(5):700-4. doi: 10.1016/j.jpeds.2005.05.032.
Our objective of this study was to describe the clinical course of severe functional constipation in early childhood. Eligible patients were 47 children (60% boys; median age, 3.5 months) who had constipation in their first year of life. Follow-up data were obtained through a standardized questionnaire. Success was defined as a period of at least 4 weeks with > or =3 painless bowel movements per week. Six months after initial evaluation, 69% of the children were recovered. After initial success, a relapse occurred in 15% of the children within 3 years. A duration of symptoms <3 months before referral correlated significantly with better outcome. We conclude that most infants with severe constipation evaluated at a tertiary center are recovered after 6 months. Early therapeutic intervention may beneficially contribute to the resolution of constipation.
我们这项研究的目的是描述幼儿期严重功能性便秘的临床病程。符合条件的患者为47名在出生后第一年内出现便秘的儿童（60%为男孩；中位年龄3.5个月）。随访数据通过标准化问卷获得。成功定义为至少持续4周，每周有≥3次无痛排便。初始评估6个月后，69%的儿童康复。初次成功后，15%的儿童在3年内复发。转诊前症状持续时间<3个月与更好的预后显著相关。我们得出结论，在三级中心接受评估的大多数严重便秘婴儿在6个月后康复。早期治疗干预可能有助于便秘的缓解。
